DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and CYP4A22

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001010969.2	Gene:	CYP4A22 / 284541	HGNCID:	20575	Length:	519	Species:	Homo sapiens

Alignment Length:	494	Identity:	140/494 - (28%)
Similarity:	228/494 - (46%)	Gaps:	62/494 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLLALSLYLLYVFERQSRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEMINEHLHD- 71
            ||:.|..|||    .||..:..| .::|.||:....||                   |.|..||
Human    30 LLIKAAQLYL----HRQWLLKAL-QQFPCPPSHWLFGH-------------------IQEFQHDQ 70

  Fly    72 ------HRAK---------LWMG-TKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLF 120
                  .|.|         :|.| .::.|.|   .|...:...:...:....|:.....:..||.
Human    71 ELQRIQERVKTFPSACPYWIWGGKVRVQLYD---PDYMKVILGRSDPKSHGSYKFLAPRIGYGLL 132

  Fly   121 TSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLDTI 185
            ....:.|...|:::.|||:..::|.:|.:.....|::|....:.......::..|.:|..|||||
Human   133 LLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTI 197

  Fly   186 CETALGVSVGSQSSAKSE-YLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHGF 249
            .::|.......|....|: |:.|:..:..::...::|.|:.|..|:..||..:......:..|..
Human   198 MKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQH 262

  Fly   250 TEGIIQKRIDEINQDAENRNYQSSDAELDGVKRT--LCFLDTLLLSKGPDGKPLTVKDIREEVDT 312
            |:.:||.|..::.:          :.||:.:||.  |.|||.|||:|..:|..|:.||:|.||||
Human   263 TDQVIQLRKAQLQK----------EGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDT 317

  Fly   313 IIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETL 377
            .:|.|.|.||:.:::.:|.:..||:||:|||||:..:.|...|  |:...:.|:.:...||||.|
Human   318 FMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGAS--ITWNHLDQMPYTTMCIKEAL 380

  Fly   378 RMYPSGPLTARKATANCTIND-FFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAIGAEPKIE 441
            |:||..|...|:.:...|..| ..:|||..|::|...:......:|:..||.|.|:|.|:.....
Human   381 RLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHSH 445

  Fly   442 ATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEP 480
            |  |:||..|:|:|:|:::||..||:..|..|..|...|
Human   446 A--FLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLP 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	131/467 (28%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	131/467 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154749
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750