DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp312a1 and Cyp4f6

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_006241111.1	Gene:	Cyp4f6 / 266689	RGDID:	708365	Length:	538	Species:	Rattus norvegicus

Alignment Length:	537	Identity:	165/537 - (30%)
Similarity:	255/537 - (47%)	Gaps:	66/537 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LGFG--------LLLLA-----LSLYLLYVFERQSRIDRLTHKWPAPPALP--FIGHLHILAKLV 53
            ||.|        ||||.     |:..|.:::.......|| ..:|.||. |  |.|||.::..
  Rat    10 LGMGSLTASPWHLLLLGGASWILARILAWIYTFYDNCCRL-RCFPQPPK-PSWFWGHLTLMKN-- 70

  Fly    54 GPHPLRRATEMINEHLHDHRAKL----------WMGTK---LYLVDCNPKDIQALCSAQQLL--Q 103
                        ||......|.|          |:|..   |.||  :|..|..|..|...:  :
  Rat    71 ------------NEEGMQFIAHLGRNFRDIHLSWVGPVYPILRLV--HPNVIAPLLQASAAVAPK 121

  Fly   104 KTNDYRVFENWLCEGLFTSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESG 168
            :...|...:.||.:||..|..|||:|.|:::.|||::.::|.:|.:|.|....:.....:....|
  Rat   122 EMTLYGFLKPWLGDGLLMSAGEKWNHHRRLLTPAFHFDILKSYVKIFNKSVNTMHAKWQRLTAKG 186

  Fly   169 D-QIDFLQLISCFTLDTICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKR 232
            . ::|..:.||..|||::.:.........|.| .|||:.|:..:..:|.||.:..|....|::..
  Rat   187 SARLDMFEHISLMTLDSLQKCIFSFDSNCQES-NSEYIAAILELSSLIVKRQRQPFLYLDFLYYL 250

  Fly   233 TSHYKREQELIKTLHGFTEGIIQKRIDEINQDAENRNYQSSDAELD--GVKRTLCFLDTLLLSKG 295
            |:..:|.::....:|.||:.:|::|...:|.       |..|..|.  ...:||.|:|.|||:|.
  Rat   251 TADGRRFRKACDVVHNFTDAVIRERRSTLNT-------QGVDEFLKARAKTKTLDFIDVLLLAKD 308

  Fly   296 PDGKPLTVKDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISI 360
            ..||.|:..|||.|.||.:|||.|.||:.|::.:||:..|||:|:|||:||..:....:.|.|..
  Rat   309 EHGKGLSDVDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVRELLRDREPEEIEW 373

  Fly   361 EQVRQLEFLEACIKETLRMYPSGPLTARKATANCTIND-FFIPKGSDVIISPIYMGRCKDFFPDP 424
            :.:.||.||..||||:||::|...|.:|..:.:..:.| ..||||:..:||...:......:|||
  Rat   374 DDLAQLPFLTMCIKESLRLHPPVLLISRCCSQDIVLPDGRVIPKGNICVISIFGVHHNPSVWPDP 438

  Fly   425 MVFKPDRWAIGAEPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEPLGERQVKLK 489
            .|:.|.|:......|.....||||.||.|:|:||.:||..:|:.||..|..|...| .:::.:.|
  Rat   439 EVYNPFRFDPENPQKRSPLAFIPFSAGPRNCIGQTFAMSEIKVALALTLLRFCVLP-DDKEPRRK 502

  Fly   490 LNFVITLH-----TVEP 501
            ...::...     .|||
  Rat   503 PELILRAEGGLWLRVEP 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	154/493 (31%)
Cyp4f6	XP_006241111.1	p450	53..515	CDD:278495	151/487 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348583
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740