DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and CYP4X1

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_828847.1	Gene:	CYP4X1 / 260293	HGNCID:	20244	Length:	509	Species:	Homo sapiens

Alignment Length:	516	Identity:	145/516 - (28%)
Similarity:	242/516 - (46%)	Gaps:	63/516 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFWLGFGLLLLALSLYLLYVFERQSRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEMI 65
            :|.|..| ||.|:.|||     |:.|:.|....:||||...|:||    .|.:....:.:..|:|
Human    19 VFCLALG-LLQAIKLYL-----RRQRLLRDLRPFPAPPTHWFLGH----QKFIQDDNMEKLEEII 73

  Fly    66 NEHLHDHRA-KLWMG-------------TKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLC 116
            .::   .|| ..|:|             .|..|...:||        .|.|||.:     ...|.
Human    74 EKY---PRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPK--------SQYLQKFS-----PPLLG 122

  Fly   117 EGLFTSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGD-QIDFLQLISCF 180
            :||......||...|:::.|.|::.::|.::.|.....:::|....|...:.| .::..:.|:..
Human   123 KGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSM 187

  Fly   181 TLDTICETALGVSVGSQ-SSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIK 244
            :||.|.:.|.......| :|....|..|:..:..||..||.::.|.:..|||.:....|.|:|.:
Human   188 SLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSR 252

  Fly   245 TLHGFTEGIIQKRIDE----INQD-AENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLTVK 304
            .|:.:|:.|||:|...    :.|| ...|.||.             |||.:|.:|...|...:..
Human   253 VLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQD-------------FLDIVLSAKDESGSSFSDI 304

  Fly   305 DIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFL 369
            |:..||.|.:..|.|..|.::::.:|.:.|:||||:||||||..:.|...|  |:.:|:.::.:.
Human   305 DVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSS--ITWDQLGEMSYT 367

  Fly   370 EACIKETLRMYPSGPLTARKATANCTIND-FFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWA 433
            ..|||||.|:.|:.|..:|..:...|..| ..:|.|..|::|...:......:.:|.||.|.|::
Human   368 TMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFS 432

  Fly   434 IGAEPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEPLGERQVKLKLNFVI 494
            .....:.....::||.||:|:|:||.:||:.||:.:|.:|.:|...|...|.:....:|::
Human   433 QENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFIL 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	133/482 (28%)
CYP4X1	NP_828847.1	p450	47..501	CDD:306555	133/482 (28%)
CYP4X1	NP_828847.1	heme binding region	447..460		7/12 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154712
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840