DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and erg11

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_592990.1	Gene:	erg11 / 2542599	PomBaseID:	SPAC13A11.02c	Length:	495	Species:	Schizosaccharomyces pombe

Alignment Length:	530	Identity:	102/530 - (19%)
Similarity:	198/530 - (37%)	Gaps:	122/530 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLLALSLYLLYVF----ERQSRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEMINEH 68
            ||.:||:.|:.|:.    .|.|:...:...|     :||:|  ..:|..:.|:...|
pombe     9 LLSIALAWYVGYIINQLTSRNSKRPPIVFHW-----IPFVG--SAVAYGMDPYVFFR-------- 58

  Fly    69 LHDHRAKLWMGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSGFEKWSH---- 129
              :.|||.   ..::...|..:.:.|....|     .||: :|...|.:   .:..|.:||
pombe    59 --ECRAKY---GDVFTFVCMGRKMTAFLGVQ-----GNDF-LFNGKLAD---LNAEEAYSHLTTP 109

  Fly   130 -----------------RRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQI-DFLQL 176
                             .:|.:.....::..:.:|.:...:....|:....|....:.: |.|:.
pombe   110 VFGKDVVYDIPNHVFMEHKKFIKSGLGFSQFRSYVPLILNEMDAFLSTSPDFGPGKEGVADLLKT 174

  Fly   177 ISCFTLDTICETALGVSV--GSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIF--------- 230
            :...|:.|...|..|..|  |..:.....|.|        :|:....:    :|:|
pombe   175 MPVMTIYTASRTLQGAEVRKGFDAGFADLYHD--------LDQGFSPV----NFVFPWLPLPRNR 227

  Fly   231 KRTSHYKREQELIKTLHGFTEGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKG 295
            :|...:|               |:||...:|.:|      :.|..|..|..    .:.||:..|.
pombe   228 RRDRAHK---------------IMQKTYLKIIKD------RRSSTENPGTD----MIWTLMSCKY 267

  Fly   296 PDGKPLTVKDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISI 360
            .||:||...:|...:..::..|...:|.|:.:.:..:...||..:...||...|.|::..  :..
pombe   268 RDGRPLKEHEIAGMMIALLMAGQHTSAATIVWVLALLGSKPEIIEMLWEEQKRVVGENLE--LKF 330

  Fly   361 EQVRQLEFLEACIKETLRMYPSGPLTARKATANCTI--NDFFIPKGSDVIISPIYMGRCKDFFPD 423
            :|.:.:..|...|:||||::|......||...:..:  :...||..:.::.:|......:::|..
pombe   331 DQYKDMPLLNYVIQETLRLHPPIHSHMRKVKRDLPVPGSKIVIPANNYLLAAPGLTATEEEYFTH 395

  Fly   424 PMVFKPDRW---------------AIGAEPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLL 473
            ...|.|.||               ..|...|..|:.::||.||...|:|:::|.:.|..:::..:
pombe   396 ATDFDPKRWNDRVNEDENAEQIDYGYGLVTKGAASPYLPFGAGRHRCIGEQFAYMHLSTIISKFV 460

  Fly   474 RNFLFEPLGE 483
            .::.:..:|:
pombe   461 HDYTWTLIGK 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	93/499 (19%)
erg11	NP_592990.1	CypX	28..495	CDD:225035	96/511 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960