Protein Alignment Cyp312a1 and Cyp3a18

DIOPT Version :10

• Sequence 1: NP_649030.1
• Gene: Cyp312a1 / 40005
• FlyBaseID: FBgn0036778
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_665725.2
• Gene: Cyp3a18 / 252931
• RGDID: 628709
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 531
• Identity: 131/531 - (24%)
• Similarity: 242/531 - (45%)
• Gaps: 113/531 - (21%)

  Fly     9 LLLALSLYLLYVFERQSRIDRLTHKWPAPPALPFIGHLHILAK---LVGPHPLRRATEMIN---- 66
            :|||.||.|.|::...|                     |.|.|   :.||.|:.....:.|
  Rat    13 VLLATSLMLFYIYGTYS---------------------HGLFKKLGIPGPKPVPLFGTIFNYGDG 56

  Fly    67 -----EHLHDHRAKLW---MGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSG 123
                 :..:....|:|   .|.:.:|...:|:.|:.:     |:::.  |.||.|..|.|  ..|
  Rat    57 MWKFDDDCYKKYGKIWGFYEGPQPFLAIMDPEIIKMV-----LVKEC--YSVFTNRRCFG--PMG 112

  Fly   124 F----------EKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLIS 178
            |          |:|...|.|:.|.|....:|:...:..:....||.|:.:....|:.|:...:..
  Rat   113 FMKKAITMSEDEEWKRLRTILSPTFTSGKLKEMFPLMRQYGDTLLKNLRREEAKGEPINMKDIFG 177

  Fly   179 CFTLDTICETALGVSVGSQSSAKSEYLDAVKSIL-----------VIIDKRLKNIFYRNSF-IFK 231
            .:::|.|..|:.||:|.|.::.:..::...|.||           |::...|..|:...:| ||.
  Rat   178 AYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFQIFDPFLLSVVLFPFLTPIYEMLNFSIFP 242

  Fly   232 RTS--HYKREQELIKTLHGFTEGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTLL--- 291
            |.|  .:|:   .:||:.       :.|:|. ||                 |..:.||..::
  Rat   243 RQSMNFFKK---FVKTMK-------KNRLDS-NQ-----------------KSRVDFLQLMMNTQ 279

  Fly   292 LSKGPDG-KPLTVKDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKS 355
            .|||.:. |.|:..::..:....||||:|.|:|:::|.||.:...|..|::.:.|:      |::
  Rat   280 NSKGQESQKALSDLEMAAQAIIFIFGGYDATSTSISFIMYELATRPNVQKKLQNEI------DRA 338

  Fly   356 ----EPISIEQVRQLEFLEACIKETLRMYPSGPLTARKATANCTINDFFIPKGSDVIISPIY-MG 415
                .|::.:.:.::|:|:..:.|:||:||......|.:..:..||..|||||: |:..||| :.
  Rat   339 LPNKAPVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSKKDVEINGVFIPKGT-VVTIPIYPLH 402

  Fly   416 RCKDFFPDPMVFKPDRWAIGAEPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEP 480
            |..:::.:|..|.|:|::...:..|:...::||..|.|:|:|.|:|::.:|:.:..:|:||..:|
  Rat   403 RNPEYWLEPEEFNPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQP 467

  Fly   481 LGERQVKLKLN 491
            ..:.|:.||::
  Rat   468 CEKTQIPLKIS 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_649030.1	CYP4	75..504	CDD:410721	116/453 (26%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	116/456 (25%)