DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_663708.1	Gene:	Cyp4x1 / 246767	RGDID:	628719	Length:	507	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	140/489 - (28%)
Similarity:	231/489 - (47%)	Gaps:	60/489 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLLALSLYLLYVFERQSRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEMINEHLHDH 72
            :|:.|:.|||     |:.|:.|....:|.|.|...:||    .|.:....:.:..|::.|  :..
  Rat    25 VLMQAVKLYL-----RRQRLLRDLRPFPGPTAHWLLGH----QKFLQEDNMEKLDEIVKE--YPC 78

  Fly    73 RAKLWMG-------------TKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSGF 124
            ....|:|             .|::|...:||       .|.|      :::...:|..||.....
  Rat    79 AFPCWVGPFQAFFYIYDPDYAKIFLSRTDPK-------TQYL------HQLMTPFLGRGLLNLDG 130

  Fly   125 EKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAK-FAESGDQIDFLQLISCFTLDTICET 188
            .:|...|.::.|||:..::|..|.:......::|....| :......|:..:.|:..|||.|.:.
  Rat   131 PRWFQHRCLLTPAFHQDILKPCVDMMAHSVNMMLDKWEKTWTTQETTIEVFEHINLMTLDIIMKC 195

  Fly   189 ALGVSVGSQSSAKSE-YLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHGFTEG 252
            |.|.....|.:...| |:.|...:..||..||.|.::.:..|||.:......|||.|.:|..||.
  Rat   196 AFGQETNCQINGTYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGKVIHQCTEK 260

  Fly   253 IIQKR----IDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLTVKDIREEVDTI 313
            |||.|    .|::|||    :.|:|..          |||.:|.::..|.|..:..|:|.||:|.
  Rat   261 IIQDRKKTLKDQVNQD----DTQTSQN----------FLDIVLSAQAGDEKAFSDADLRSEVNTF 311

  Fly   314 IFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLR 378
            ::.|.|.:|.::::.:|.:.|:||||.|||.|:.|:.|...|  |:.||:.::.:...|||||||
  Rat   312 MWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILGDGSS--ITWEQLDEIPYTTMCIKETLR 374

  Fly   379 MYPSGPLTARKATANCTIND-FFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAIGAEPKIEA 442
            :.|..|..:|:.:...|:.| ..:|.|..|::|...:......:.||.||.|.|:......:...
  Rat   375 LIPPIPSISRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWKDPKVFDPLRFTKENSEQRHP 439

  Fly   443 TTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNF 476
            ..|:||.:|.|:|:||::||:.||:.:|..|..|
  Rat   440 CAFLPFSSGPRNCIGQQFAMLELKVAIALTLLRF 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	132/462 (29%)
Cyp4x1	NP_663708.1	CYP4B-like	66..500	CDD:410771	126/439 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348521
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840