Protein Alignment Cyp312a1 and CYP51A1

DIOPT Version :9

• Sequence 1: NP_001262008.1
• Gene: Cyp312a1 / 40005
• FlyBaseID: FBgn0036778
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_000777.1
• Gene: CYP51A1 / 1595
• HGNCID: 2649
• Length: 509
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 129/556 - (23%)
• Similarity: 226/556 - (40%)
• Gaps: 143/556 - (25%)

  Fly     8 LLLLALSLYLLYVFE-RQSRIDRLTHKWPAPP----ALPFIGHLHILAKLVGPHPLRRATEMINE 67
            |:..|.:|.|:|:.. ....:.:|.....:||    .:||:||    |...|..|:    |.: |
Human    37 LIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGH----AIAFGKSPI----EFL-E 92

  Fly    68 HLHDHRAKLWMGTKL-----YLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSGFEK- 126
            :.::....::..|.:     ||:.   .|..||     |....|:....|: :...|.|..|.|
Human    93 NAYEKYGPVFSFTMVGKTFTYLLG---SDAAAL-----LFNSKNEDLNAED-VYSRLTTPVFGKG 148

  Fly   127 ---------WSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTL 182
                     :..::|::....|....||.|::.||:::....:   :.|||:: :..:.:|...:
Human   149 VAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFES---WGESGEK-NVFEALSELII 209

  Fly   183 DTICETALGVSVGSQSSAKSEYLDAVKSILVIID--------------------------KRLKN 221
            .|......|..:.||.:.|      |..:...:|                          :.:|:
Human   210 LTASHCLHGKEIRSQLNEK------VAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKD 268

  Fly   222 IFYRNSFIFKRTSHYKREQELIKTLHGFTEGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCF 286
            |||:        :..||.|.             |::||:|
Human   269 IFYK--------AIQKRRQS-------------QEKIDDI------------------------- 287

  Fly   287 LDTLLLSKGPDGKPLTVKDIREEVDTIIFGGFDLTATT---LNFFM-YNMTLHPEHQQRCREEVW 347
            |.|||.:...||:|||..::...:..::..|...::||   :.||: .:.||    |::|..|..
Human   288 LQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTL----QKKCYLEQK 348

  Fly   348 SVCGKDKSEPISIEQVRQLEFLEACIKETLRMYPSGPLTARKATANCTINDFFIPKGSDVIISPI 412
            :||| :...|::.:|::.|..|:.|||||||:.|...:..|.|....|:..:.||.|..|.:||.
Human   349 TVCG-ENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPT 412

  Fly   413 YMGRCKDFFPDPMVFKPDRWAIGAEPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFL 477
            ...|.||.:.:.:.|.|||:........|...::||.||...|:|:.:|.|.:|.:.:.:||.:.
Human   413 VNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYE 477

  Fly   478 FE------PLGERQVKLKLNFVITLHTVEPYLCRAK 507
            |:      |        .:|:...:||.|..:.|.|
Human   478 FDLIDGYFP--------TVNYTTMIHTPENPVIRYK 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	121/524 (23%)
CYP51A1	NP_000777.1	p450	67..483	CDD:299894	116/494 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1934
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860