Protein Alignment Cyp312a1 and CYP4B1

DIOPT Version :9

• Sequence 1: NP_001262008.1
• Gene: Cyp312a1 / 40005
• FlyBaseID: FBgn0036778
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 154/520 - (29%)
• Similarity: 244/520 - (46%)
• Gaps: 59/520 - (11%)

  Fly     7 GLLLLALSLYLLYVFERQSRIDRLTHKWPAPPALPFIGH-LHI-----LAKLVG-------PHPL 58
            ||:|:...|.|:::..|:..:.:...|:|.||.....|| |.|     |.|:|.       .||
Human    19 GLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHP- 82

  Fly    59 RRATEMINEHLHDHRAKLWMGTKL-YLVDCNPKDIQALCSAQQLLQKTND-YRVFENWLCEGLFT 121
                             ||.|..: :|....|...:|:.|...  .|..| |..|..|:..||..
Human    83 -----------------LWFGQFIGFLNIYEPDYAKAVYSRGD--PKAPDVYDFFLQWIGRGLLV 128

  Fly   122 SGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLDTIC 186
            ....||...||::.|.|:|.::|.:||||.:.:||:|....:.|..|...|....:....|:|:.
Human   129 LEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLM 193

  Fly   187 ETALG-VSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHGFT 250
            :...| ...|...|..|.|..||..:.:::.:||.:..|.|.||:..|.|.:|.....:..|..|
Human   194 KCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHT 258

  Fly   251 EGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLTVKDIREEVDTIIF 315
            :.:|::|...:..:...:..|:        :|.|.|||.||.::..|...|:..|:|.||||.:|
Human   259 DQVIRERKAALQDEKVRKKIQN--------RRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMF 315

  Fly   316 GGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLRMY 380
            .|.|.|.:.:::|:|.|.|:||||.||||||..:.|  ..:....:.:.::.:|..||||:.|:|
Human   316 EGHDTTTSGISWFLYCMALYPEHQHRCREEVREILG--DQDFFQWDDLGKMTYLTMCIKESFRLY 378

  Fly   381 PSGPLTARKATANCT-INDFFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAIGAEPKIEATT 444
            |..|...|:.:...| ::...:|.||.:.:....:.|....:|||.||...|::.....|.....
Human   379 PPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFA 443

  Fly   445 FIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEPLGERQVKLKLNFVITLHTVEPYL-CRAKN 508
            |:||.||.|:|:||::||..:|:|.|..|..|.|. |...::.:|:          |.| .|:||
Human   444 FMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFS-LDPSRLPIKM----------PQLVLRSKN 497

  Fly   509  508
            Human   498  497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	144/487 (30%)
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	147/492 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154801
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750