DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and Cyp51

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_064394.2	Gene:	Cyp51 / 13121	MGIID:	106040	Length:	503	Species:	Mus musculus

Alignment Length:	533	Identity:	131/533 - (24%)
Similarity:	226/533 - (42%)	Gaps:	97/533 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLLALSLYLLYVFE-RQSRIDRLTHKWPAPP----ALPFIGHLHILAKLVGPHPLRRATEMINE 67
            |:..|.:|.|:|:|. ....:.:|.....:||    .:||:||    |...|..|:    |.: |
Mouse    31 LIACAFTLSLVYLFRLAVGHMVQLPAGAKSPPHIYSPIPFLGH----AIAFGKSPI----EFL-E 86

  Fly    68 HLHDHRAKLWMGTKL-----YLVDCNPKDIQALCSAQQLLQKTNDYRVFENW--LCEGLFTSGFE 125
            :.::....::..|.:     ||:.   .|..||.    ...|..|....|.:  |...:|..|..
Mouse    87 NAYEKYGPVFSFTMVGKTFTYLLG---SDAAALL----FNSKNEDLNAEEVYGRLTTPVFGKGVA 144

  Fly   126 K------WSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLDT 184
            .      :..::||:....|....||:|.:.||:::....:   :.|||:: :..:.:|...:.|
Mouse   145 YDVPNAIFLEQKKIIKSGLNIAHFKQYVPIIEKEAKEYFQS---WGESGER-NVFEALSELIILT 205

  Fly   185 ICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFI---------FKRTSHYKREQ 240
            ......|..:.||.:.|...|.|          .|...|...:::         |:|.....||
Mouse   206 ASHCLHGKEIRSQLNEKVAQLYA----------DLDGGFTHAAWLLPAWLPLPSFRRRDRAHRE- 259

  Fly   241 ELIKTLHGFTEGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLTVKD 305
              ||.:  |.:.|.::|:.:  :.||:                  .|.|||.|...||:|||.::
Mouse   260 --IKNI--FYKAIQKRRLSK--EPAED------------------ILQTLLDSTYKDGRPLTDEE 300

  Fly   306 IREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLE 370
            |...:..::..|...::||..:..:.:......|::|..|..:|||:| ..|::.:|::.|..|:
Mouse   301 ISGMLIGLLLAGQHTSSTTSAWMGFFLAKDKPLQEKCYLEQKAVCGED-LPPLTYDQLKDLNLLD 364

  Fly   371 ACIKETLRMYPSGPLTARKATANCTINDFFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAIG 435
            .|||||||:.|......|.|....|:..:.||.|..|.:||....|.||.:.:.:.|.|||:...
Mouse   365 RCIKETLRLRPPIMTMMRMAKTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWAERLDFNPDRYLQD 429

  Fly   436 AEPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFE------PLGERQVKLKLNFVI 494
            .....|...::||.||...|:|:.:|.|.:|.:.:.:||.:.|:      |        .:|:..
Mouse   430 NPASGEKFAYVPFGAGRHRCVGENFAYVQIKTIWSTMLRLYEFDLINGYFP--------TVNYTT 486

  Fly   495 TLHTVEPYLCRAK 507
            .:||.|..:.|.|
Mouse   487 MIHTPENPVIRYK 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	122/501 (24%)
Cyp51	NP_064394.2	p450	67..477	CDD:299894	115/465 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1934
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.860