DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp312a1 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus

Alignment Length:	511	Identity:	145/511 - (28%)
Similarity:	241/511 - (47%)	Gaps:	35/511 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WLGFGLLLLALSLYLLYVFERQSRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEMINE 67
            |....:|::.:...|..:|.|| ::.|....:|.||.....||...:.|..|   |.:......:
Mouse    16 WASVVILMVTVLKLLSLLFRRQ-KLARALDSFPGPPKHWLFGHALEIQKTGG---LDKVVTWTEQ 76

  Fly    68 HLHDHRAKLWMGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSGFEKWSHRRK 132
            ..:.|  .||:|..:..::....|......::...:....|..|..|:.:||......||...||
Mouse    77 FPYAH--PLWLGQFIVFLNIYEPDYAKAVYSRGDPKAAYVYDFFLQWIGKGLLVLEGPKWFQHRK 139

  Fly   133 IVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLDTICETALGVSVGSQ 197
            ::.|.|:|.::|.:||:|.:.:|::|....|.|......|....:....|||:.:...|......
Mouse   140 LLTPGFHYDVLKPYVAIFAESTRVMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFGKGDSGL 204

  Fly   198 SSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHGFTEGIIQKRIDEIN 262
            |.:.:.|..||..:.:::.:|:.:..|.|.||:..|.|.:|.....:..|..|:.:|::|...:.
Mouse   205 SHSDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACQIAHDHTDHVIRQRKAALQ 269

  Fly   263 QDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPLTVKDIREEVDTIIFGGFDLTATTLNF 327
            .:.|.:..|.        :|.|.|||.||.::...|..|:..|:|.||||.:|.|.|.|.:.:::
Mouse   270 DEKEQKKLQE--------RRHLDFLDILLGARDESGIKLSDADLRAEVDTFMFEGHDTTTSGISW 326

  Fly   328 FMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLRMYPSGPLTARKATA 392
            |:|.|.|:|.|||||||||..:.|...|  ...:.:.|:.:|..|:||..|:||..|...|:.:.
Mouse   327 FLYCMALYPMHQQRCREEVREILGDRDS--FQWDDLAQMTYLTMCMKECFRLYPPVPQVYRQLSK 389

  Fly   393 NCT-INDFFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWA----IGAEPKIEATTFIPFMAGA 452
            ..| ::...:|.||.:.:....:.|....:|||.||.|.|::    .|..|    ..|:||.||.
Mouse   390 PVTFVDGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSPENMTGRHP----FAFMPFSAGP 450

  Fly   453 RSCMGQRYAMVMLKMVLAHLLRNFLFEPLGERQVKLKLNFVITLHTVEPYLCRAKN 508
            |:|:||::||..:|:|.|..|..|.|.| ...::.:|         |...:.|:||
Mouse   451 RNCIGQQFAMNEMKVVTALCLLRFEFSP-DPSKIPIK---------VPQLILRSKN 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	135/474 (28%)
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	138/479 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845254
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750