Protein Alignment Cyp312a1 and Cyp4a12b

DIOPT Version :10

• Sequence 1: NP_649030.1
• Gene: Cyp312a1 / 40005
• FlyBaseID: FBgn0036778
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_758510.2
• Gene: Cyp4a12b / 13118
• MGIID: 3611747
• Length: 508
• Species: Mus musculus
• Alignment Length: 500
• Identity: 150/500 - (30%)
• Similarity: 247/500 - (49%)
• Gaps: 33/500 - (6%)

  Fly     8 LLLLALSLYLLYVFERQSRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEMINEHLHDH 72
            ||||......||: .||..:.. |.::|:||:....||     |::....|:.....|.......
Mouse    27 LLLLLFKTAQLYL-HRQWLLSS-TQQFPSPPSHWLFGH-----KILKDQDLQDILTRIKNFPSAC 84

  Fly    73 RAKLWMGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSGFEKWSHRRKIVMPA 137
            ...|| |:|:.:...:| |...|...:...:....||....|:..||.....:.|...|:::.||
Mouse    85 PQWLW-GSKVRIQVYDP-DYMKLILGRSDPKAHGSYRFLAPWIGRGLLLLDGQTWFQHRRMLTPA 147

  Fly   138 FNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLDTICETALGVSVGSQSSAK- 201
            |:|.::|.:..:......::|....:.......::..|.|:..|||||.:.|.......|...|
Mouse   148 FHYDILKPYTEIMADSVHVMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSHEGSVQLDRKY 212

  Fly   202 SEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHGFTEGIIQKRIDEINQDAE 266
            ..|:.||:.:..:...|::|||::|..|::.:|:........:..|..|:.:|:.|..:: ||.|
Mouse   213 KSYIQAVEDLNNLFFLRVRNIFHQNDIIYRVSSNGCLANSACQLAHDHTDQVIKSRRSQL-QDEE 276

  Fly   267 NRNYQSSDAELDGV--KRTLCFLDTLLLSKGPDGKPLTVKDIREEVDTIIFGGFDLTATTLNFFM 329
                     ||:.:  ||.|.|||.||.::..:||.|:.||:|.||||.:|.|.|.||:.:::..
Mouse   277 ---------ELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIF 332

  Fly   330 YNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLRMYPSGPLTARKATANC 394
            |.:..:||||||||:|:.|:.|...|  |:...:.::.:...||||.||:||..|..:|:.::..
Mouse   333 YALATNPEHQQRCRKEIQSLLGDGAS--ITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPV 395

  Fly   395 TIND-FFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAIGAEPKIEATTFIPFMAGARSCMGQ 458
            |..| ..:|||..|::|...:......:|:|.||.|.|:|.|:..  .:.:|:||..|||:|:|:
Mouse   396 TFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSR--HSHSFLPFSGGARNCIGK 458

  Fly   459 RYAMVMLKMVLAHLLRNFLFEPLGER------QVKLKLNFVITLH 497
            ::||..||:.:|..|..|...|...|      ::.||....|.||
Mouse   459 QFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLH 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_649030.1	CYP4	75..504	CDD:410721	132/432 (31%)
Cyp4a12b	NP_758510.2	CYP4B-like	70..503	CDD:410771	133/448 (30%)