Protein Alignment Cyp312a1 and Cyp46a1

DIOPT Version :10

• Sequence 1: NP_649030.1
• Gene: Cyp312a1 / 40005
• FlyBaseID: FBgn0036778
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_034140.1
• Gene: Cyp46a1 / 13116
• MGIID: 1341877
• Length: 500
• Species: Mus musculus
• Alignment Length: 537
• Identity: 128/537 - (23%)
• Similarity: 227/537 - (42%)
• Gaps: 95/537 - (17%)

  Fly     7 GLL------LLALSLYLLYVFERQSRIDRLTHKWPAPPALPF-IGHL-----------HIL---- 49
            |||      |||..|...:|...:||.:.:    |.||...| :|||           .:|
Mouse     4 GLLLLGSAVLLAFGLCCTFVHRARSRYEHI----PGPPRPSFLLGHLPYFWKKDEDCGRVLQDVF 64

  Fly    50 ---AKLVGPHPLRRATEMINEHLHDHRAKLWMGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVF 111
               ||..||..               |..::..|.:.:.  :|:.::....:.:..:.:..||..
Mouse    65 LDWAKKYGPVV---------------RVNVFYKTSVIVT--SPESVKKFLMSTKYNKDSKMYRAL 112

  Fly   112 ENWLCEGLFTSG------FEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQ 170
            :....|.||..|      :.:|..:||::..||:.:.:...:..|.:::..|:..:...|:....
Mouse   113 QTVFGERLFGQGLVSECDYGRWYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTP 177

  Fly   171 IDFLQLISCFTLDTICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNS---FIFKR 232
            :....:::|.|:|.:.:.|.|:.......|:.....|||.:|..|...      ||:   |:..:
Mouse   178 VSMQDMLTCATIDILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISAS------RNTLAKFMPGK 236

  Fly   233 TSHYKREQELIKTLHGFTEGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPD 297
            ....:..:|.|:.|....:..:|:|.:.:.        :..|...|.:.:.|         |..:
Mouse   237 RKQLREIRESIRLLRQVGKDWVQRRREALK--------RGEDMPADILTQIL---------KAEE 284

  Fly   298 GKPLTVKDIREEVD---TIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPIS 359
            |    .:|....:|   |....|.:.:|..|.|.:..::..||...|.:.||..|.|..:.  :.
Mouse   285 G----AQDDEVLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRH--LD 343

  Fly   360 IEQVRQLEFLEACIKETLRMYPSGPLTARKATANCTINDFFIPKGSDVIISPIYMGRCKDFFPDP 424
            .|.:.:|::|...:||:||:||....|.|.......|:...:|..:.::.|...|||...:|.||
Mouse   344 YEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDP 408

  Fly   425 MVFKPDRWAIGA-EPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEPL-GERQVK 487
            :.|.|||:..|| :|:.   |:.||..|.|||:||::|.:.:|:|:|.||:...|..: |:|
Mouse   409 LTFNPDRFGPGAPKPRF---TYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRLVPGQR--- 467

  Fly   488 LKLNFVITLHTVEPYLC 504
            ..|....||..::|.||
Mouse   468 FGLQEQATLKPLDPVLC 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_649030.1	CYP4	75..504	CDD:410721	103/442 (23%)
Cyp46a1	NP_034140.1	CYP46A1-like	61..484	CDD:410706	108/474 (23%)