DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and Cyp46a1

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_034140.1	Gene:	Cyp46a1 / 13116	MGIID:	1341877	Length:	500	Species:	Mus musculus

Alignment Length:	537	Identity:	128/537 - (23%)
Similarity:	227/537 - (42%)	Gaps:	95/537 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GLL------LLALSLYLLYVFERQSRIDRLTHKWPAPPALPF-IGHL-----------HIL---- 49
            |||      |||..|...:|...:||.:.:    |.||...| :|||           .:|
Mouse     4 GLLLLGSAVLLAFGLCCTFVHRARSRYEHI----PGPPRPSFLLGHLPYFWKKDEDCGRVLQDVF 64

  Fly    50 ---AKLVGPHPLRRATEMINEHLHDHRAKLWMGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVF 111
               ||..||..               |..::..|.:.:.  :|:.::....:.:..:.:..||..
Mouse    65 LDWAKKYGPVV---------------RVNVFYKTSVIVT--SPESVKKFLMSTKYNKDSKMYRAL 112

  Fly   112 ENWLCEGLFTSG------FEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQ 170
            :....|.||..|      :.:|..:||::..||:.:.:...:..|.:::..|:..:...|:....
Mouse   113 QTVFGERLFGQGLVSECDYGRWYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTP 177

  Fly   171 IDFLQLISCFTLDTICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNS---FIFKR 232
            :....:::|.|:|.:.:.|.|:.......|:.....|||.:|..|...      ||:   |:..:
Mouse   178 VSMQDMLTCATIDILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISAS------RNTLAKFMPGK 236

  Fly   233 TSHYKREQELIKTLHGFTEGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPD 297
            ....:..:|.|:.|....:..:|:|.:.:.        :..|...|.:.:.|         |..:
Mouse   237 RKQLREIRESIRLLRQVGKDWVQRRREALK--------RGEDMPADILTQIL---------KAEE 284

  Fly   298 GKPLTVKDIREEVD---TIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPIS 359
            |    .:|....:|   |....|.:.:|..|.|.:..::..||...|.:.||..|.|..:.  :.
Mouse   285 G----AQDDEVLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRH--LD 343

  Fly   360 IEQVRQLEFLEACIKETLRMYPSGPLTARKATANCTINDFFIPKGSDVIISPIYMGRCKDFFPDP 424
            .|.:.:|::|...:||:||:||....|.|.......|:...:|..:.::.|...|||...:|.||
Mouse   344 YEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDP 408

  Fly   425 MVFKPDRWAIGA-EPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEPL-GERQVK 487
            :.|.|||:..|| :|:.   |:.||..|.|||:||::|.:.:|:|:|.||:...|..: |:|
Mouse   409 LTFNPDRFGPGAPKPRF---TYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRLVPGQR--- 467

  Fly   488 LKLNFVITLHTVEPYLC 504
            ..|....||..::|.||
Mouse   468 FGLQEQATLKPLDPVLC 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	118/503 (23%)
Cyp46a1	NP_034140.1	p450	34..466	CDD:278495	110/480 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920