DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp312a1 and CYP4F8

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_009184.1	Gene:	CYP4F8 / 11283	HGNCID:	2648	Length:	520	Species:	Homo sapiens

Alignment Length:	540	Identity:	163/540 - (30%)
Similarity:	262/540 - (48%)	Gaps:	70/540 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WLGFG--------LLLLALSLYLL-------YVFERQSRIDRLTHKWPAPPALP-FIGH------ 45
            |||..        |||:..:.:||       |.|....|..|.   :|.|.... |:||
Human     8 WLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRC---FPQPRKQNWFLGHLGLVTP 69

  Fly    46 ----LHILAKLVGPHP---LRRATEMINEHLHDHRAKLWMGTKLYLVD-CNPKDIQALCSAQQLL 102
                |.:|.:||..:|   :|                 |:|....::: |:|..::::.:....:
Human    70 TEEGLRVLTQLVATYPQGFVR-----------------WLGPITPIINLCHPDIVRSVINTSDAI 117

  Fly   103 QKTN--DYRVFENWLCEGLFTSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFA 165
            ...:  .|:..:.||.:||..|..:||.|.|:::.|||::.::|.::.:|.|.:.|:.....:.|
Human   118 TDKDIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLA 182

  Fly   166 ESGDQ-IDFLQLISCFTLDTICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFI 229
            ..|.. :|..:.||..|||::.:.........|.. .|||:.|:..:..::.||....|....|:
Human   183 MEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEK-PSEYITAIMELSALVVKRNNQFFRYKDFL 246

  Fly   230 FKRTSHYKREQELIKTLHGFTEGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSK 294
            :..|...:|.....:.:|.||:.:||:|...:.....:...|:.     ...:||.|:|.||||:
Human   247 YFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAK-----AKSKTLDFIDVLLLSE 306

  Fly   295 GPDGKPLTVKDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPIS 359
            ..:||.|:.:|||.|.||.:|||.|.||:.|::.:||:..|||:|:|||:||..:. ||: ||..
Human   307 DKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELL-KDR-EPKE 369

  Fly   360 IE--QVRQLEFLEACIKETLRMYPSGPLTARKATANCTINDF-FIPKGSDVIISPIYMGRCKDFF 421
            ||  .:.||.||..|:||:||::|..|..||..|.:..:.|. .||||:...|:...:......:
Human   370 IEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVW 434

  Fly   422 PDPMVFKPDRWAIGAEPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLF-----EPL 481
            |||.|:.|.|:......|.....||||.||.|:|:||::||..:|:|||..|..|..     ||.
Human   435 PDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPR 499

  Fly   482 GERQVKLKLNFVITLHTVEP 501
            ...::.|:....:.|. |||
Human   500 RTPEIVLRAEDGLWLR-VEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	151/493 (31%)
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	146/476 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154729
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750