Protein Alignment Cyp312a1 and Cyp4v3

DIOPT Version :10

• Sequence 1: NP_649030.1
• Gene: Cyp312a1 / 40005
• FlyBaseID: FBgn0036778
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_598730.1
• Gene: Cyp4v3 / 102294
• MGIID: 2142763
• Length: 525
• Species: Mus musculus
• Alignment Length: 524
• Identity: 162/524 - (30%)
• Similarity: 272/524 - (51%)
• Gaps: 66/524 - (12%)

  Fly     1 MFWLGFGL----LLL-----ALSL----YLLYVFERQSRIDRLTHKW-------PAPPALPFIGH 45
            |.||..||    |||     |:||    .|:.:|   ..:.....||       ....|.|.:||
Mouse     1 MLWLWLGLSGQKLLLWGAASAVSLAGATILISIF---PMLVSYARKWQQMRSIPSVARAYPLVGH 62

  Fly    46 LHILAKLVGPHPLRRATEMI---NEHLHDHRAKLWMGTKLYLVDCNPKDIQALCSAQQLLQKTND 107
                |..:.|:......::|   .|..|....|||:|....:.....::::.:.::.:.:.|:..
Mouse    63 ----ALYMKPNNAEFFQQLIYYTEEFRHLPIIKLWIGPVPLVALYKAENVEVILTSSKQIDKSFL 123

  Fly   108 YRVFENWLCEGLFTSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQID 172
            |:..:.||..||.||...||..|||::.|.|::|:::.|:.|..:|:.||:..:.|....
Mouse   124 YKFLQPWLGLGLLTSTGSKWRTRRKMLTPTFHFTILENFLDVMNEQANILVNKLEKHVNQ----- 183

  Fly   173 FLQLISCF------TLDTICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLK------NIFYR 225
              :..:||      .||.|||||:|.::|:||:..|||:..|..:..:|.:|:|      :::|
Mouse   184 --EAFNCFFYITLCALDIICETAMGKNIGAQSNNDSEYVRTVYRMSDMIYRRMKMPWLWFDLWY- 245

  Fly   226 NSFIFKRTSHYKREQELIKTLHGFTEGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTL 290
              .:||....:||.   :|.||.||..:|.:|:.|  :.||.....:....:....:...|||.|
Mouse   246 --LVFKEGRDHKRG---LKCLHTFTNNVIAERVKE--RKAEEDWTGAGRGPIPSKNKRKAFLDLL 303

  Fly   291 LLSKGPDGKPLTVKDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKS 355
            |.....:|..|:.:||||||||.:|.|.|.||..:|:.:|.:..:||.|::..:|:..|.|: ..
Mouse   304 LSVTDEEGNRLSQEDIREEVDTFMFEGHDTTAAAINWSLYLLGTNPEVQRKVDQELDEVFGR-SH 367

  Fly   356 EPISIEQVRQLEFLEACIKETLRMYPSGPLTARKATANCTINDFFIPKGSDVIISPIYMGRCKDF 420
            .|:::|.:::|::|:..||||||::||.||.||..:.:|.:..:.:.||::.||.|..:.|...:
Mouse   368 RPVTLEDLKKLKYLDCVIKETLRVFPSVPLFARSLSEDCEVGGYKVTKGTEAIIIPYALHRDPRY 432

  Fly   421 FPDPMVFKPDRW----AIGAEPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEPL 481
            ||||..|:|:|:    :.|..|    ..::||.||.|:|:||::|::..|.:||.:||.|..|..
Mouse   433 FPDPEEFRPERFFPENSQGRHP----YAYVPFSAGPRNCIGQKFAVMEEKTILACILRQFWVESN 493

  Fly   482 GERQ 485
            .:|:
Mouse   494 QKRE 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_649030.1	CYP4	75..504	CDD:410721	138/427 (32%)
Cyp4v3	NP_598730.1	CYP4V	76..515	CDD:410773	141/442 (32%)