DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp312a1 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_598730.1	Gene:	Cyp4v3 / 102294	MGIID:	2142763	Length:	525	Species:	Mus musculus

Alignment Length:	524	Identity:	162/524 - (30%)
Similarity:	272/524 - (51%)	Gaps:	66/524 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFWLGFGL----LLL-----ALSL----YLLYVFERQSRIDRLTHKW-------PAPPALPFIGH 45
            |.||..||    |||     |:||    .|:.:|   ..:.....||       ....|.|.:||
Mouse     1 MLWLWLGLSGQKLLLWGAASAVSLAGATILISIF---PMLVSYARKWQQMRSIPSVARAYPLVGH 62

  Fly    46 LHILAKLVGPHPLRRATEMI---NEHLHDHRAKLWMGTKLYLVDCNPKDIQALCSAQQLLQKTND 107
                |..:.|:......::|   .|..|....|||:|....:.....::::.:.::.:.:.|:..
Mouse    63 ----ALYMKPNNAEFFQQLIYYTEEFRHLPIIKLWIGPVPLVALYKAENVEVILTSSKQIDKSFL 123

  Fly   108 YRVFENWLCEGLFTSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQID 172
            |:..:.||..||.||...||..|||::.|.|::|:::.|:.|..:|:.||:..:.|....
Mouse   124 YKFLQPWLGLGLLTSTGSKWRTRRKMLTPTFHFTILENFLDVMNEQANILVNKLEKHVNQ----- 183

  Fly   173 FLQLISCF------TLDTICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLK------NIFYR 225
              :..:||      .||.|||||:|.::|:||:..|||:..|..:..:|.:|:|      :::|
Mouse   184 --EAFNCFFYITLCALDIICETAMGKNIGAQSNNDSEYVRTVYRMSDMIYRRMKMPWLWFDLWY- 245

  Fly   226 NSFIFKRTSHYKREQELIKTLHGFTEGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTL 290
              .:||....:||.   :|.||.||..:|.:|:.|  :.||.....:....:....:...|||.|
Mouse   246 --LVFKEGRDHKRG---LKCLHTFTNNVIAERVKE--RKAEEDWTGAGRGPIPSKNKRKAFLDLL 303

  Fly   291 LLSKGPDGKPLTVKDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKS 355
            |.....:|..|:.:||||||||.:|.|.|.||..:|:.:|.:..:||.|::..:|:..|.|: ..
Mouse   304 LSVTDEEGNRLSQEDIREEVDTFMFEGHDTTAAAINWSLYLLGTNPEVQRKVDQELDEVFGR-SH 367

  Fly   356 EPISIEQVRQLEFLEACIKETLRMYPSGPLTARKATANCTINDFFIPKGSDVIISPIYMGRCKDF 420
            .|:::|.:::|::|:..||||||::||.||.||..:.:|.:..:.:.||::.||.|..:.|...:
Mouse   368 RPVTLEDLKKLKYLDCVIKETLRVFPSVPLFARSLSEDCEVGGYKVTKGTEAIIIPYALHRDPRY 432

  Fly   421 FPDPMVFKPDRW----AIGAEPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEPL 481
            ||||..|:|:|:    :.|..|    ..::||.||.|:|:||::|::..|.:||.:||.|..|..
Mouse   433 FPDPEEFRPERFFPENSQGRHP----YAYVPFSAGPRNCIGQKFAVMEEKTILACILRQFWVESN 493

  Fly   482 GERQ 485
            .:|:
Mouse   494 QKRE 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	147/470 (31%)
Cyp4v3	NP_598730.1	p450	51..517	CDD:278495	147/471 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844933
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840