Protein Alignment Cyp312a1 and cyp46a1.4

DIOPT Version :10

• Sequence 1: NP_649030.1
• Gene: Cyp312a1 / 40005
• FlyBaseID: FBgn0036778
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: XP_002933245.2
• Gene: cyp46a1.4 / 100498621
• XenbaseID: XB-GENE-29072485
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 507
• Identity: 121/507 - (23%)
• Similarity: 224/507 - (44%)
• Gaps: 73/507 - (14%)

  Fly     3 WLGFGLLLL------ALSLYLLYVFERQSRIDRLTHKWPAPPALPF-IGHLHILAKLVGPHPLRR 60
            |:..|.||:      |...|..|:.....:.|.:    |.||...| :||:..|:|
 Frog    12 WVYSGFLLIIIGAVVAFLAYCAYIKYMHLKYDDI----PGPPRDSFLLGHIPTLSK--------- 63

  Fly    61 ATEMINEHLHD---HRAKLW-------MGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFEN-- 113
             .|.....:||   |.|:::       :..::.:...:|:.::....:.:..:....|....|
 Frog    64 -AEENYSVVHDLFLHWAEIYGPVFKINILHRVMIYSTSPESVKECLMSSKYPKDPYTYNQLFNLF 127

  Fly   114 ---WLCEGLFTS-GFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFL 174
               :|.:||.|. ..:.|.|:|:|:.|||:.|.:|:.:.:|.:::..::..:.:.|:...::...
 Frog   128 GKRFLGKGLLTDPDHDHWYHQRRIMDPAFSNTYLKEMIGIFNERAEQMMEKLEEKADGHQEVSMH 192

  Fly   175 QLISCFTLDTICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKRE 239
            .:|:..|||.|.:.|.|:.:|.....|:::.:|:..:|..:.:.::|.:.:  :..|..:..:..
 Frog   193 SIINRVTLDVITKVAFGMDLGLVEGNKTDFPNAISKVLTGMMRYMQNPYMQ--YFPKHWAFVREV 255

  Fly   240 QELIKTLHGFTEGIIQKRI------DEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDG 298
            ||....|....:..|.:|.      :|:.:|...:..|.  |||:........||..:
 Frog   256 QESADLLRKTGKECISQRKKAMQNGEELPKDILTKILQC--AELENALDDEIMLDNFI------- 311

  Fly   299 KPLTVKDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQV 363
                         |....|.:.||..|:|.:..:|..||...:.|.||..|.|..:.  ||.:.:
 Frog   312 -------------TFFIAGQETTANQLSFTVMELTRQPEIMTKLRMEVDEVIGFKRD--ISYDDI 361

  Fly   364 RQLEFLEACIKETLRMYPSGPLTARKATANCTINDFFIPKGSDVIISPIYMGRCKDFFPDPMVFK 428
            :.|.::...:||:||.||.||.|:|....:.......||.|..:..:...|||.:.||.||..|.
 Frog   362 QNLNYMTQVLKESLRFYPPGPGTSRYLKEDTIFEGIKIPGGVSITFNTYVMGRMEKFFQDPCKFD 426

  Fly   429 PDRWAIGA-EPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFE 479
            |:|:...| :|..   .:.||..|.|||:||.::.:..|::|:.|::.|.||
 Frog   427 PERFHPAAVKPYF---CYFPFALGPRSCLGQIFSQLEAKVILSKLIQRFEFE 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp312a1	NP_649030.1	CYP4	75..504	CDD:410721	100/425 (24%)
cyp46a1.4	XP_002933245.2	CYP46A1-like	72..498	CDD:410706	104/433 (24%)