DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mus304 and ATRIP

DIOPT Version :9

Sequence 1:	NP_524135.3	Gene:	mus304 / 40003	FlyBaseID:	FBgn0002901	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_569055.1	Gene:	ATRIP / 84126	HGNCID:	33499	Length:	791	Species:	Homo sapiens

Alignment Length:	791	Identity:	157/791 - (19%)
Similarity:	253/791 - (31%)	Gaps:	285/791 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 PPP----PPQKKPTSLDMDAIFADDDDF----DFLAVTLMDSEPQKMPEPKTSTSRITTSSISVQ 157
            |||    ||.|:.......|....||.|    ||.|..|.:.:              |.:|.::.
Human    22 PPPGTGHPPSKRARGFSAAAAPDPDDPFGAHGDFTADDLEELD--------------TLASQALS 72

  Fly   158 QKTTTTTTINATQSRQQEHQLKFLMD--------------------RIEALKRENAQLEKNLGDS 202
            |.......:::      :|::..|:|                    .:|.|:.:..:|::.:...
Human    73 QCPAAARDVSS------DHKVHRLLDGMSKNPSGKNRETVPIKDNFELEVLQAQYKELKEKMKVM 131

  Fly   203 KERNEIKSGEVSLLRDELKHLRQQLQASKMEKLALADETNRDCNKKVAEAAKQIAAKDIELKIKN 267
            :|...||:||:.:|||.|......|:..:.....|..|..:..:.|..|.:|::.:...||:.|:
Human   132 EEEVLIKNGEIKILRDSLHQTESVLEEQRRSHFLLEQEKTQALSDKEKEFSKKLQSLQSELQFKD 196

  Fly   268 AEFSKLKTQQKAHERS--------------MNSSMSILQAAPDPLEKRLSLRLNR-LNIHRSVP- 316
            ||.::|:|:.:..||:              .|.|:.|...|..|...:.|..... .:.:.|:|
Human   197 AEMNELRTKLQTSERANKLAAPSVSHVSPRKNPSVVIKPEACSPQFGKTSFPTKESFSANMSLPH 261

  Fly   317 GLKTDNG------------------SVFEYSENE---DQTKKRRNH-----FELELKQLLLHYAR 355
            ..:|::|                  |:.:....:   |..::|.|.     ..|.|||.|:..:.
Human   262 PCQTESGYKPLVGREDSKPHSLRGDSIKQEEAQKSFVDSWRQRSNTQGSILINLLLKQPLIPGSS 326

  Fly   356 LQ----------------AKPESVDNLLPRI--LSSVGKVFTEFA----SYAQSLDFP------- 391
            |.                .:|....:.|..:  |.:.|.....|:    ..||:|.|.
Human   327 LSLCHLLSSSSESPAGTPLQPPGFGSTLAGMSGLRTTGSYDGSFSLSALREAQNLAFTGLNLVAR 391

  Fly   392 HNC-----------MLYPYNPHNLEEEVHRISL----------------------------THQS 417
            :.|           ..:|.  ..|...||.:.|                            ||.|
Human   392 NECSRDGDPAEGGRRAFPL--CQLPGAVHFLPLVQFFIGLHCQALQDLAAAKRSGAPGDSPTHSS 454

  Fly   418 CLYDNEKAVP------LRRFIATLA-----LICRREERISRGLTEWKENDLGLLDMAIEAITKL- 470
            |:....:..|      |..|..|..     |:|.....:|..|     :.:|....|.|....|
Human   455 CVSSGVETNPEDSVCILEGFSVTALSILQHLVCHSGAVVSLLL-----SGVGADSAAGEGNRSLV 514

  Fly   471 -------------GFSYEVGQHFGLLEALTSLLNSLLQENALLQH-NEELLFDLLKQLVFTRPSP 521
                         |.:.:.|||    ..|..||:.|...:|...| ...:|...||.||
Human   515 HRLSDGDMTSALRGVADDQGQH----PLLKMLLHLLAFSSAATGHLQASVLTQCLKVLV------ 569

  Fly   522 WVFAELSSC-FLSCLRHPQLMDKMCVNSPKDCFVSDRVRSVYRFGPDSCLLQVYAGLLELCFFSE 585
             ..||.:|| ||.                             ||   .|:.||    |..|...|
Human   570 -KLAENTSCDFLP-----------------------------RF---QCVFQV----LPKCLSPE 597

  Fly   586 TPLRQDYFQL-LLKIGGNHVRFAFE-CFKNPPDFILEMLPYFADDGD-----------EDSSDGT 637
            |||......: ||.:..:|.:.|.: |..:....:|.:..|.....|           |......
Human   598 TPLPSVLLAVELLSLLADHDQLAPQLCSHSEGCLLLLLYMYITSRPDRVALETQWLQLEQEVVWL 662

  Fly   638 LMKTGTSLSFNSTGAVQGSVSNGSTSASVSNPNQNSNSSTTQRGKGCECYVKLCLSAVTIVFQVM 702
            |.|.|          ||..:.          |...||         |:|.|:: :.|:|:   ::
Human   663 LAKLG----------VQSPLP----------PVTGSN---------CQCNVEV-VRALTV---ML 694

  Fly   703 HQWMLHSRKAG 713
            |:..|..|:||
Human   695 HRQWLTVRRAG 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus304	NP_524135.3	ATP-synt_B	<178..303	CDD:304375	34/158 (22%)
ATRIP	NP_569055.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..57		12/34 (35%)
		Tropomyosin_1	113..>212	CDD:403808	26/98 (27%)
		Interaction with CINP. /evidence=ECO:0000269\|PubMed:19889979	118..156		10/37 (27%)
		EEXXXDL motif	769..776
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	1.056642	Normalized mean entropy	S8661
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR28594
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	3.010