DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mus304 and atrip

DIOPT Version :9

Sequence 1:	NP_524135.3	Gene:	mus304 / 40003	FlyBaseID:	FBgn0002901	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_001038332.1	Gene:	atrip / 558534	ZFINID:	ZDB-GENE-050208-331	Length:	737	Species:	Danio rerio

Alignment Length:	842	Identity:	169/842 - (20%)
Similarity:	289/842 - (34%)	Gaps:	269/842 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 FPPP---PPPQKK--PTSLDMDAIFADDD-----------------------DFDFLAVTLMDSE 135
            |||.   ..||.|  |...|.|..|..||                       .||  ||.....|
Zfish     3 FPPSKRLKGPQVKTGPDPFDDDIDFTQDDLEQIDIIASQAISADVQNSGSKRSFD--AVLACADE 65

  Fly   136 PQKMPEPKTSTSRITTSSISVQQKT------TTTTTINATQSRQQEHQLKFLMDR------IEAL 188
            |.|.|             :...:||      .:::|.|.|.::::|........:      .:.|
Zfish    66 PSKAP-------------VRSGRKTFALGDACSSSTYNNTHAQRKEPSADGPSSKDGDDLYYKQL 117

  Fly   189 KRENAQLEKNLGDSKERNEIKSGEVSLLRDELKHLRQQLQASKMEKLALADETNRDCNKKVAEAA 253
            :.:.|:|:|.|.:.:|...:|:||:.:|||.||...|:.:..:..::.|..|..:..:.:..|.:
Zfish   118 EEQQAELKKKLKEVEEEILMKNGEIRVLRDSLKQAHQEREQQRQAQIILEKEKTQAQSDREKELS 182

  Fly   254 KQIAAKDIELKIKNAEFSKLKTQQKAHER-SMNSSMSILQAAPDPLEKRLSLRLN-RLNIHRSV- 315
            :::.:...||..|.||.::::.:.::.|| ...|.....||...||.:....:.| ...|.:..
Zfish   183 RKVQSLQSELHFKEAEMNEMRGKLQSVERGGKQSGTPARQAVKSPLSRTFMTKENFSAEISKRTS 247

  Fly   316 ---PGLKTDNGSVFEYSENEDQTKKRRNHFELE-----LKQLLLHYA----------RLQAKPES 362
               ||..:||.::......|:|..::....:|:     |.:|||...          .|...|::
Zfish   248 PVKPGPSSDNAALSRCLLPEEQRSQQCIASDLQKEGCVLLKLLLQQPLDPSVLGLCHLLSISPDA 312

  Fly   363 VDNLLPRI-LSSVGKVFTEFASYAQSLDFPHNCMLYPYNPHNLEE---------EVHRISLTHQ- 416
            :.|:|.:. ..|.|.:.|..:|......||.:    |...|:|:.         .:|..|...:
Zfish   313 LPNMLTQHGYISPGSLSTSSSSSTDLRSFPRS----PSQFHHLQSLAMSALTALSLHEPSTVSRP 373

  Fly   417 -SCLYDNEKAV---PLRRFIATLALICRREERISRGLTEWKENDLGLLDMAIEAITKLGFSYEVG 477
             ||    ..||   ||..|  .::..|:..|                   ..::.||...
Zfish   374 SSC----PSAVHFLPLLSF--HISTYCQSLE-------------------VFDSSTKSSL----- 408

  Fly   478 QHFGLLEALT-SLLNSLLQENALLQHNEELLFDLLKQLVFTRPSPWVFAELSSCFLSCLRHPQLM 541
             |.|.|...: |.|:|:|:|:  |...|||....|:.|.               .:.|.....|.
Zfish   409 -HSGSLSGSSDSSLSSVLEES--LSGQEELALAALRALQ---------------HIVCYSKEALE 455

  Fly   542 DKMCVNSPKDCF---------------VSDRVRSV---YRFGPDSCLLQVYAGLLE--------- 579
            |.:.:.:||:..               ::|...|.   :|....||..::.:.|.|
Zfish   456 DVIRMQTPKNMLGEIQNQMPVLRRLLQLADPAFSTAAGHREALVSCSWRILSVLAERAEDNLISR 520

  Fly   580 LCFFSETPLRQDYFQLLLKIGGNH--VRF-----------AFECFKNPPDFILEMLPYFADDGDE 631
            |.....:|:......|.......|  |||           :..|..:.|...|::..|.....|:
Zfish   521 LQVVMSSPVLSKCLTLETTYSIVHLCVRFLSFIICNDEMASKLCLHDYPCPFLKIFQYVTSRPDK 585

  Fly   632 DSSDG-------TLMKTGTSLSFNSTGAVQGSVSNGSTSASVSNPNQNSNSSTTQRGKGCECYVK 689
            .|::.       .:::..|.|.....|          |.|::..             ..|:|..:
Zfish   586 SSTEDAWSRLELVVIRLLTKLFTQRAG----------TWAALCE-------------SSCQCVNE 627

  Fly   690 LCLSAVTIVFQVMHQWMLHSRKAGTEEVG---------EISRIAVHLLSLVFHEYYLTCLFRDSE 745
            :    |..|..|:|:..|.::..|.:.||         ::.|.|:.||
Zfish   628 V----VRTVVVVLHRQWLKTKCRGGQTVGTQIWSSPGLQVLREALMLL----------------- 671

  Fly   746 ETTKHYLSLICNWWSEHANLLGFQSIHLRLLNQLVKA---HFMLKPLHLEAKPNNPVNDLSE 804
                |:|.|..:.:|||.    ...:|  :.:|::.|   .|.|.|            ||||
Zfish   672 ----HWLLLKDSAFSEHC----LDVLH--MYDQVIPAIRDTFRLLP------------DLSE 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus304	NP_524135.3	ATP-synt_B	<178..303	CDD:304375	30/131 (23%)
atrip	NP_001038332.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR28594
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	2	2.060