DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mus304 and Atrip

DIOPT Version :9

Sequence 1:	NP_524135.3	Gene:	mus304 / 40003	FlyBaseID:	FBgn0002901	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_766362.2	Gene:	Atrip / 235610	MGIID:	1925349	Length:	785	Species:	Mus musculus

Alignment Length:	821	Identity:	160/821 - (19%)
Similarity:	278/821 - (33%)	Gaps:	239/821 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 RKKKGGTEVDIGNSEVTFSEFAPTFQGSTSTQQMFPPPPPPQKKPTSLDMDAIFADDDDFDFLAV 129
            ||:.||.|...|.|...  |..|:.:..:.::...|.|..|..:......|    |.::.|.||.
Mouse    11 RKQSGGLEPFPGLSRSI--ENPPSKRARSFSETTVPDPEDPFGEHAEFTAD----DLEELDILAS 69

  Fly   130 TLMDSEPQKMPEPKTSTSRITTSSISVQQKTTTTTTINATQSRQQEHQLKFLMD--RIEALKREN 192
            ..:...|            :...::|...|......:..:..|:....:. :.|  .:|.|:.:.
Mouse    70 QALSQCP------------VAPRNLSSAHKVRRLDGLPNSPIRKSREDIP-VKDNFELEVLQIQY 121

  Fly   193 AQLEKNLGDSKERNEIKSGEVSLLRDELKHLRQQLQASKMEKLALADETNRDCNKKVAEAAKQIA 257
            .:|::.|...:|...||:||:.:|||.|:.....|:..|.....|..|..:..::|..|.::::.
Mouse   122 KELKEKLKAMEEEILIKNGEIKILRDSLRQTESVLEEQKRSHFLLEQEKTQALSEKEKEFSRKLQ 186

  Fly   258 AKDIELKIKNAEFSKLKTQQKAHERS--------------MNSSMSILQAAPDP------LEKRL 302
            :...||:.|:||.::|:|:.:::.|:              ..||:.:...|..|      ...:.
Mouse   187 SLQSELQFKDAEMNELRTKSQSNGRTNKPAAPSVSHVSPRKGSSVVLKSEACSPHVGKTTFPTKE 251

  Fly   303 SLRLNRLNIHRSVPGLKTDNGSVF----EYSENEDQTKKRRNH------FELELKQLLLHYARLQ 357
            |...|....|    ..:|:.|..|    |.|:|       :||      .:.:::|.:|....:|
Mouse   252 SFSANTPLFH----PCQTEAGHRFLVGQEVSDN-------KNHSLGGSLMKQDVQQRILADGWMQ 305

  Fly   358 AK-----------------------------------------PESVDNL-----LPRILSSVGK 376
            .|                                         |..:..|     |..|.||.|.
Mouse   306 RKDAQGSILINLLLKQPLVPGSSLGLCHLLSSCPEVPTGTLLQPPGLSTLPGTSGLRTISSSDGP 370

  Fly   377 VFTEFASYAQSLDF-----------PHN-----CMLYPYNPHNLEEEVHRI-------------- 411
            ........||:|.|           .|:     ..::|.  |.|...||.:
Mouse   371 FSPSALREAQNLAFTGLNLVARTESSHDGDMAGRRVFPL--HQLPGAVHLLPLVQFFVGLHCQAL 433

  Fly   412 --------------SLTHQSCLYDNEKAVPLRRFIATLALICRREERISRGLTEWKENDLGLLDM 462
                          |.||.||:....:|.|              |:.| .||..:....|.:|..
Mouse   434 QDLAPAKKSGVPGDSATHTSCMSSGVEASP--------------EDSI-HGLESFSVASLSVLQN 483

  Fly   463 ------AIEAITKLGFSYEVGQHFGLLEALTSLLNSLLQENALLQHNEELLFDLLKQLVFTRPSP 521
                  |:..:...|...|.....|.|....:...|..:|:|..|....||..||:.:..:..:.
Mouse   484 LVCHSGAVVCLLLSGMGTEAAAREGNLVQTCADTTSASREDAHDQDQHPLLKMLLQLMASSSAAS 548

  Fly   522 WVFAELSSCFLSCLRHPQLMDKMCVNSPKDCFVSDRVRSVYRFGPDSCLLQVYAGLLELCFFSET 586
            ..|.  :|....||:   ::.|:..|:..|.        :.||   ||:..|    |..|..|..
Mouse   549 GHFQ--ASVLGLCLK---VLVKLAENASSDL--------LPRF---SCVFPV----LPQCLGSAL 593

  Fly   587 PLRQDYFQL-LLKIGGNHVRFAFECFKNPPD-FILEMLPYFADDGDEDSSDGTLMKTGTSLSFNS 649
            ||......: ||.:..:|...|::...:|.. .:|.:..|.....|..:|:...::
Mouse   594 PLPCVLLAVELLSVLLDHDSLAWQLCSHPEGCLLLRLYMYITSRPDRTASETQWLQ--------- 649

  Fly   650 TGAVQGSVSNGSTSASVSNPNQNSNSSTTQRGKGCECYVKLCLSAVTIVFQVMHQWMLHSRKAG- 713
               ::..|.......||.:|      :....|..|.|.|: .:.|:|:   ::|:..|..|:||
Mouse   650 ---LEQEVVWLLAKLSVQSP------APAGIGSDCHCNVE-AVRALTV---MLHRQWLTVRRAGG 701

  Fly   714 --TEEVGEISR------IAVHLLSL-----------VFHEY 735
              |.:..:..|      :.:|.||.           |.|:|
Mouse   702 PRTHQQKQTIRCLRDTVLLLHSLSQKDKLFTVHCVEVLHQY 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus304	NP_524135.3	ATP-synt_B	<178..303	CDD:304375	32/146 (22%)
Atrip	NP_766362.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		12/43 (28%)
		Prefoldin	117..205	CDD:298833	24/87 (28%)
		Interaction with CINP. /evidence=ECO:0000250	118..156		11/37 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..227		3/25 (12%)
		EEXXXDL motif	763..770
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	1.056642	Normalized mean entropy	S8661
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR28594
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	3.010