DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RpIIIC53 and Polr3d

DIOPT Version :9

Sequence 1:	NP_649028.3	Gene:	RpIIIC53 / 40002	FlyBaseID:	FBgn0036775	Length:	415	Species:	Drosophila melanogaster
Sequence 2:	NP_001026823.1	Gene:	Polr3d / 306012	RGDID:	1311816	Length:	398	Species:	Rattus norvegicus

Alignment Length:	450	Identity:	110/450 - (24%)
Similarity:	181/450 - (40%)	Gaps:	121/450 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ASGSTTNNGQSGGGARPLETLNG---------MTRLTP-------ARDLTLGGRGAGTASKKVFA 67
            :.|:......:.||.|||  |:|         ...|||       :|||||||     ..||.|.
  Rat     2 SEGNAAGEPSNPGGPRPL--LSGGRGLVGRRPAPPLTPGRLPSIRSRDLTLGG-----VKKKTFT 59

  Fly    68 PNLNAVRNKNANVKTSKDTTQPRSGRRGGRGNGTGATRGRGGNSAGGGNSTLIQTQGLFSEGAGD 132
            ||:.:.:.|.   :..::.|..:..|...|      .|.|.|:..|.|...:||:..:|.:|..:
  Rat    60 PNIISRKIKE---EPKEEVTMKKEKRERDR------DRQREGHGRGRGRPEVIQSHSIFEQGPAE 115

  Fly   133 VHVRRSTGNGTA-YARGGEEVSVTRKRVDRKDDKSQAERIKELLGESD----------------- 179
            :..::...:.|. .:..|....:..|:..|:.|: :.::|..:|.:.|
  Rat   116 MMKKKGNWDKTVDMSDMGPSHIINIKKEKRETDE-ETKQILRMLEKDDFIDDPGLKNDTRNMPVQ 179

  Fly   180 ---ASGGELSEEEANKTEMALRPILL---KEGLWVTQKTPIAKQE---------------IASST 223
               |..|.|.:||:.:.:  ::|...   :|.:.|.......|:|               .|..|
  Rat   180 LPLAHSGWLFKEESEEPD--VKPFSAGPKEEDMEVDVPAVKVKEEPRDEEEEAKVKAPPRAARKT 242

  Fly   224 STLKDTLAVAQHLQQLHVAAQAASLEEPPLQYGRYPRTIGNFLDSSEAQIFLMQLPDVLPCVGD- 287
            ..|...::||:.|::|.:                          :.|.::..:||||.||  |.
  Rat   243 PGLPKDVSVAELLRELSL--------------------------TKEEELLFLQLPDTLP--GQP 279

  Fly   288 DSEDPEPSKGDHQA----------TSESEPASPADKCSNGPKGSVLRQLEEGQIGKILRYKSGRV 342
            .::|.:|.|.:.|.          ..:.|.....:.|:       |..|.|||:||:|..|||:|
  Rat   280 PTQDIKPVKTEVQGEDGQMVVIKQEKDRETRLAENACT-------LADLTEGQVGKLLIRKSGKV 337

  Fly   343 KLQLGDTRFDLDMGLDPGFLQELMSVTANREQRSGNMINLGPIQAKLKATPDWVHLFQQQ 402
            :|.||....|:.||....|||||:||... :.|:|.|..||.::.||..:||:..|...:
  Rat   338 QLLLGKVTLDVTMGTTCSFLQELVSVGLG-DSRTGEMTVLGHVKHKLVCSPDFESLLDHK 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpIIIC53	NP_649028.3	RNA_pol_Rpc4	272..395	CDD:282926	46/133 (35%)
Polr3d	NP_001026823.1	RNA_pol_Rpc4	263..389	CDD:398686	47/135 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353356
Domainoid	1	1.000	67	1.000	Domainoid score	I9632
eggNOG	1	0.900	-	-		E1_KOG3122
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I5041
OMA	1	1.010	-	-		QHG48400
OrthoDB	1	1.010	-	-		D1381418at2759
OrthoFinder	1	1.000	-	-		FOG0003960
OrthoInspector	1	1.000	-	-		oto96258
orthoMCL	1	0.900	-	-		OOG6_107056
Panther	1	1.100	-	-	LDO	PTHR13408
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.810