DRSC/TRiP Functional Genomics Resources

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Protein Alignment LMNA and LamC

DIOPT Version :9

Sequence 1:NP_733821.1 Gene:LMNA / 4000 HGNCID:6636 Length:664 Species:Homo sapiens
Sequence 2:NP_001260974.1 Gene:LamC / 36615 FlyBaseID:FBgn0010397 Length:640 Species:Drosophila melanogaster


Alignment Length:624 Identity:219/624 - (35%)
Similarity:335/624 - (53%) Gaps:78/624 - (12%)


- Green bases have known domain annotations that are detailed below.


Human     1 METPSQRRATRS---GAQASS-----TPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENA 57
            :.|...|.:|.:   ||..||     :|.||||.:|.||||:||.||||||.||||:|:||.||:
  Fly     8 LNTRVSRASTSTPVGGASTSSRVGATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLENENS 72

Human    58 GLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTK 122
            .|...:..:::.|:||.|.:||.||.||..|||.||..|||:|:|::::.::.||..:||.|..|
  Fly    73 RLTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDK 137

Human   123 KEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEM 187
            |..:...|:...:..|...|......:.:|::::..|.:..:|..:..:|...|.:.:|||:.|.
  Fly   138 KTKEATVAENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQLDDLRKQLEAET 202

Human   188 LRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQH 252
            |.|||.||:.|:::|||.|:..::::||.||:.|.:..:.|||....|::|::|..:|||||.|:
  Fly   203 LARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQYEAKLQQSLQELRDQY 267

Human   253 EDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKE 317
            |.|:...::|:|..|..::.|.:.:|.|.:.....|.||::..|.:||.|:|:|..|:...|...
  Fly   268 EGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLN 332

Human   318 AKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEG 382
            |::|:||:.|..||....:.:|..|.|:..||..|..||.|||.|:|||::||:||.||.|||.|
  Fly   333 ARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCG 397

Human   383 EEERL-------------------RLSPSPTSQRSRGRASSHSSQTQG--GGSVTKKRK--LEST 424
            ||.||                   .|:.|.:|:..|...|...|.|.|  |.|..|:|:  ::.:
  Fly   398 EERRLNIESPGRPTTDSGISSNGSHLTASASSRSGRVTPSGRRSATPGISGSSAVKRRRTVIDES 462

Human   425 ESR--SSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKF 487
            |.|  |.:|.:|...|.:.:.|.|.||:|::|.||..|:.::..||:.|..||:. |.::|....
  Fly   463 EDRTLSEYSVNAAAKGDLEIIEADVEGRFIKLHNKGTEEINLTGWQLTRIAGDEE-LAFKFSRGS 526

Human   488 TLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVED 552
            .:..|..||||:..||..|.||.:||.|.:  |...||:|:.|.|:..|       ||.:::   
  Fly   527 KVLGGASVTIWSVDAGTAHDPPNNLVMKKK--WPVANSMRSVLANADKE-------VRVLSI--- 579

Human   553 DEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTC 591
                                      ||      .||||
  Fly   580 --------------------------YN------TCGTC 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LMNANP_733821.1 Interaction with MLIP. /evidence=ECO:0000269|PubMed:21498514 1..130 62/136 (46%)
Head 1..33 15/39 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25 10/31 (32%)
Filament 30..386 CDD:365827 142/355 (40%)
Coil 1A 34..70 18/35 (51%)
Linker 1 71..80 4/8 (50%)
Coil 1B 81..218 46/136 (34%)
Linker 2 219..242 6/22 (27%)
Coil 2 243..383 56/139 (40%)
Necessary and sufficient for the interaction with IFFO1. /evidence=ECO:0000269|PubMed:31548606 259..331 22/71 (31%)
Tail 384..664 65/233 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 384..442 21/82 (26%)
Nuclear localization signal. /evidence=ECO:0000255 417..422 2/6 (33%)
LTD 434..541 CDD:395746 38/106 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 552..576 0/23 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 598..619
LamCNP_001260974.1 Filament 45..401 CDD:278467 142/355 (40%)
ATP-synt_B <67..>142 CDD:304375 32/74 (43%)
MreC <178..>224 CDD:302802 18/45 (40%)
LTD 473..574 CDD:279300 38/110 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 270 1.000 Domainoid score I1835
eggNOG 1 0.900 - - E1_KOG0977
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 398 1.000 Inparanoid score I1952
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48052
OrthoDB 1 1.010 - - D204815at33208
OrthoFinder 1 1.000 - - FOG0001052
OrthoInspector 1 1.000 - - mtm8670
orthoMCL 1 0.900 - - OOG6_103212
Panther 1 1.100 - - O PTHR45721
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X632
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.840

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