Protein Alignment ASIC2 and ppk15

DIOPT Version :10

• Sequence 1: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_001097937.1
• Gene: ppk15 / 43188
• FlyBaseID: FBgn0039424
• Length: 483
• Species: Drosophila melanogaster
• Alignment Length: 551
• Identity: 115/551 - (20%)
• Similarity: 186/551 - (33%)
• Gaps: 198/551 - (35%)

Human    69 LRHMCAGRTAAGGS--------FQRRALWVL-AFCTSFG---LLLSWSSNRLLYWLSFPSHTRVH 121
            ::..|...|.||.:        |..|..|:: .|.:|.|   |::.       |..|||  ||..
  Fly    24 IKDYCTNCTLAGFAYIANSRLHFMERIFWLICVFMSSLGCYQLIMG-------YQRSFP--TRAV 79

Human   122 REWSRQLP------FPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSEL---LRG 177
            ......||      ||||:||             :|.|.|:    |.|.  ....::.|   :.|
  Fly    80 SIVYESLPPFSKWKFPAVSVC-------------ELAYRGN----LFPK--FEEYITSLGVDVTG 125

Human   178 DEPRRQWFRKLADFR-----LFLPPRHFE-GISA----------------------AFMDRLGHQ 214
            |.|        .|..     |..|..:.| |:..                      ..:...|..
  Fly   126 DYP--------YDVETGVSILLFPALYNENGLKGKCGTVHKNCTDACAKCPSDNYRQILTWYGAN 182

Human   215 LEDMLLSCKYRGEL--CGPHNFSSVFTKYGKCYMFNS---GEDG--------------KPLLTTV 260
            ..|:.:.||...|.  |..| |..:.|.:|:|||.||   .|.|              |.::..:
  Fly   183 CSDLFVECKLSHEPFDCCRH-FLPLLTPFGRCYMLNSLLNNEPGSKHWLPNELDPAHQKAVINVI 246

Human   261 KGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAP--GFQTFV 323
                 ..|::.:.:...|.:|                  |:...||.|..:..|::.  .|....
  Fly   247 -----TRLDVQISVINAEDIP------------------HTAFFPPGIPLITEGLSKYMQFNQVA 288

Human   324 ATQEQRLTYLPPPWGECRSSEMGLDFFP----------VYSITACRIDCETRYIVENCNC-RMVH 377
            ...:..:..:.|....|        |||          .||.:.|..:|..|..::.||| ..::
  Fly   289 MKNDPDVKDIDPKIRSC--------FFPEEIPADSLYKSYSFSVCITECIRRLQMKACNCTSFLY 345

Human   378 MPGDAPFCTPEQHKEC-------------AEPALGLLA--EKDSN-YCLCRTPCN---LTRYNKE 423
            .|...|     ::.:|             .:|...:|.  .|.:| .|.|...||   :|...:.
  Fly   346 NPNADP-----RYPDCDLEGFLCLEKTRMIKPDSRVLVNNNKGNNASCGCLPSCNDGDITTIYEP 405

Human   424 LSMVKIPSKTSAKYLEKKFNKSEKYISENILV-LDIFFEALNYETIEQKKAYEVAALLGDIGGQM 487
            |..|:.|:|.....|:..|..:::|..:::.. ||:                     :..:||.:
  Fly   406 LLFVRNPNKYYNGTLDMPFLPTDQYRRQSLRTPLDV---------------------VVSMGGML 449

Human   488 GLFIGASILTILELFDYIYELIKEKLLDLLG 518
            |||:|||||:.:|   ::|......|.::||
  Fly   450 GLFLGASILSAIE---FVYYFTVRPLSNMLG 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	115/551 (21%)
ppk15	NP_001097937.1	ASC	27..466	CDD:459966	111/535 (21%)