Protein Alignment ASIC2 and ppk10

DIOPT Version :10

• Sequence 1: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_001033894.1
• Gene: ppk10 / 3885617
• FlyBaseID: FBgn0065110
• Length: 485
• Species: Drosophila melanogaster
• Alignment Length: 541
• Identity: 112/541 - (20%)
• Similarity: 175/541 - (32%)
• Gaps: 174/541 - (32%)

Human    66 LHGLRHMCAGRTAAGGSFQRRALWVLAFCTS--FGLLLSWSSNRLLYWLSFPSHTRVHRE---WS 125
            :||.|::..........|    ||::....|  |.:::..||....|..|  :|..:.|.   |:
  Fly    28 IHGFRYLTDSMLILFEKF----LWLILLIASIYFCIIVCLSSIDRYYTKS--THIGIERNYIFWN 86

Human   126 RQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWL--GLLLPNRTARPLVSELLRGDEPRRQW--FR 186
            ..|  |:||||..:.|..       .|:|.:..  |:..|.|       ::|        |  ..
  Fly    87 TTL--PSVTVCPVDRLNI-------TYFADYCRNNGIKGPQR-------DIL--------WDFLE 127

Human   187 KLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELC---------GPHNFS------- 235
            .||:....    :|:.|..  .:::...:||:.|..::..||.         .| ||:
  Fly   128 NLANSTYI----NFQNIPQ--NEQIDQIIEDIGLKPEHYTELIYNLTYDRTYEP-NFNERIRCMD 185

Human   236 --------SVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEY---------LPIW 283
                    .|.|::|.||:.||      .||                  :||         .|.:
  Fly   186 GAMFIHVRQVLTEWGLCYLGNS------KLT------------------EEYSSRYFIFGKYPEY 226

Human   284 GETEETTFEAGVKVQIHSQSEPPFIQELGF---------------------------GVAPGFQT 321
            .:.|........:|....|.:..:.. |||                           |:.....|
  Fly   227 NKYEYENIRLPYQVGSFFQKDTQYAL-LGFKGPAIIAFAHSAFEVMKVDSNSDYAYDGILYDLST 290

Human   322 FVATQEQRLTY-LPPPWGECR-SSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMP----G 380
            ...|.|..|.. .......|| ..|..|..||.|:...|:.:|......:.|.|.....|    .
  Fly   291 EEITAEDNLEQDTTVAMRRCRFPHESNLTHFPFYTRNICQQECRINLAYKICKCIPHFYPNRIAN 355

Human   381 DAPFCTPEQHKEC----AEPALGLLAE--KDSN--YCLCRTPCNLTRYNKELSMVKIPSKTSAKY 437
            ..|.|..:..:.|    |...|.|..|  |..|  .|.|...|    ::..::|..:...:.||.
  Fly   356 PKPVCDYKTLRSCFPHHASFFLKLYEENGKHENPAICYCEQNC----HDSVVTMKSMNPMSGAKQ 416

Human   438 LEKKFNKSEKYISENILVLDIFFEALNYETIEQKK-----AYEVAALLGDIGGQMGLFIGASILT 497
            |                 |.....|::.:|..|.:     .:.:..||..|||..|||:|.|:|.
  Fly   417 L-----------------LGGIGSAVSVKTWPQSRLRRQVIFSLTDLLVSIGGTAGLFLGFSVLG 464

Human   498 ILELFDYIYELIKEKLLDLLG 518
            .:|:   ||......:..:||
  Fly   465 FVEV---IYFFTIRIVFQILG 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	112/541 (21%)
ppk10	NP_001033894.1	ASC	22..471	CDD:459966	109/528 (21%)