Protein Alignment ASIC2 and ppk16

DIOPT Version :10

• Sequence 1: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_001334673.1
• Gene: ppk16 / 3885612
• FlyBaseID: FBgn0065108
• Length: 531
• Species: Drosophila melanogaster
• Alignment Length: 544
• Identity: 129/544 - (23%)
• Similarity: 197/544 - (36%)
• Gaps: 166/544 - (30%)

Human    66 LHGLRHMCAGRTAAGGSFQRRALW----VLAFCTSFGL-LLSWSSNRLLYWLS------------ 113
            |||..::    |....|...|..|    :||..||..| ::||      ||..
  Fly    65 LHGFSYI----TRQDISRHERWFWLVVVILAIITSIVLVVVSW------YWSQETPTVTVIESSH 119

Human   114 FPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLL----------------L 162
            ||:       |:  :||||||:||     |.::||...      |.||                |
  Fly   120 FPT-------WN--IPFPAVTICN-----FNKISKSKA------LSLLDQMQVPVGINRSELHNL 164

Human   163 PNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLE----DMLLSCK 223
            .|.|..|:  :.:..::..:::.|.|:             ::...::||..||.    :|:.||.
  Fly   165 FNLTLLPV--DTMISNDSLQKYDRILS-------------LNNLTLNRLTQQLSPDCIEMISSCI 214

Human   224 YRG--ELCGPHNFSSVFTKYGKCYMFN--SGEDG------------KPLLTTVKGGTG--NGLEI 270
            ::|  ..| ...|..:.|..|:|..||  .|...            :|...|   |.|  .||.:
  Fly   215 WKGINTRC-ESLFQRIDTMEGQCCTFNYFGGISNNFPEKIAYQVPKRPYRVT---GCGYPTGLSV 275

Human   271 MLDIQQDEYLPIWGETEETTFEA-GVKVQIH-------SQSEPPFI---QELGFGVAPGFQTFVA 324
            :|:....:|   :|    |.|.. |.::.:|       ..||...:   :|....:.|  ::..|
  Fly   276 LLNPMISDY---YG----TFFSGFGFRLLLHDAYNFPDENSETKVVTTTRESFVRINP--ESTYA 331

Human   325 TQEQRLTYLPPPWGECR-SSEMGLDFFPVYSITACRIDCETRYIVENCNC--RMVHMPGDAPFCT 386
            |.:.|...|  ....|. .|||.:.....||...|..:|..|..|:.|.|  ..|:..|....|.
  Fly   332 TNDIRRMDL--SLRNCLFGSEMTMHGLRRYSFINCMFECRVRMTVDLCGCLPPYVYNNGSYKVCG 394

Human   387 PEQHKEC--------------AEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKY 437
            ..| ..|              ...:|.::.|.||..|.|...|....|..|    ....:....|
  Fly   395 VLQ-TNCIIHSKRLFSHALANLNFSLSIVRETDSFPCGCLPDCQSNHYVSE----STTGRLDISY 454

Human   438 LEKK--FNKSEKYISENILVLDIFFEAL---NYET-IEQKKAYEVAALLGDIGGQMGLFIGASIL 496
            ...:  ||.:    ::.|| |.:||..|   .|.| |.|    ...:.|...||.:||.:|.||:
  Fly   455 FANRPTFNNA----TDRIL-LHVFFSDLMSTRYRTDIFQ----NWLSALASFGGLLGLIMGFSIV 510

Human   497 TILELFDYIYELIKEKLLDLLGKE 520
            |   .|::||.|....:.:.:.:|
  Fly   511 T---AFEFIYFLTFRPVFNYINRE 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	129/544 (24%)
ppk16	NP_001334673.1	ASC	59..518	CDD:459966	126/529 (24%)