Protein Alignment ASIC2 and ppk26

DIOPT Version :10

• Sequence 1: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_648125.3
• Gene: ppk26 / 38835
• FlyBaseID: FBgn0035785
• Length: 597
• Species: Drosophila melanogaster
• Alignment Length: 579
• Identity: 136/579 - (23%)
• Similarity: 215/579 - (37%)
• Gaps: 186/579 - (32%)

Human    66 LHGLRHMCAGRTAAGGSFQR----RALW----VLAFCTSFGLLLS----WSSNRLLYWLSF-PSH 117
            :||:|::        |..:|    |..|    ||:..|...|.|:    |::|.::  :|| ...
  Fly    80 IHGIRYL--------GEKKRPLLERLFWISVLVLSVFTCVKLTLNIWDKWNNNPVI--VSFAEKS 134

Human   118 TRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLY-----YAGHWLGLL-----------LPNRT 166
            |.|   |  |:||||||||.....|....:..|.|     :..:..|::           ..::.
  Fly   135 TPV---W--QIPFPAVTVCPETKTRREIFNFTDSYHQVRDFQSNVSGIVDLSDKQKGLYGAVSQV 194

Human   167 ARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELCGP 231
            ..|.:.::..|::.||.  .::.|....:.| ||               :|..|:||:|.   .|
  Fly   195 CEPHLHDVTLGNKTRRG--MEIIDALTEVSP-HF---------------DDTYLNCKWRN---SP 238

Human   232 HNFSSVFTKY----GKCYMFNS-----------------------------GEDG-------KPL 256
            ...|.:|.|:    |.|:.|||                             .|||       .|.
  Fly   239 VKCSDIFHKFVTEDGVCFSFNSLSPAEIFRAEGIIPDFIFREENRLSMDWNVEDGYSASADTSPY 303

Human   257 LTTVKG-GTGNGLEIML---DIQQDEYL--PIWGETEETTFEAGVKVQIHSQSEP---------- 305
            ...|.| |...||.:.:   :|..|:..  |:          .|.|:.:|:..:.
  Fly   304 PNRVLGPGARAGLYLFMGGAEIDFDDMCRGPV----------QGFKILLHTPGDVAQVSKQYFRI 358

Human   306 PFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECR-SSEMGLDFFPVYSITACRIDCETRYIVE 369
            ||.||:...:.|.    :.|....|.:..|...:|. ..|..|.:|.:||.:.|.::|...:.:.
  Fly   359 PFDQEVLISIRPK----IITTSDGLKHYEPNRRQCYFQKERELRYFNIYSQSNCELECLANFTLT 419

Human   370 NCNC------RMVHMP--GDAPFCTPEQHKECAEPALGLLAE------------KDSNYCLCRTP 414
            .|.|      |.|:||  |||......|    ||..| ||.|            :....|.|...
  Fly   420 KCGCVKFSMPRNVNMPVCGDASLKCYNQ----AEDEL-LLREFTQGLVNAGENTRGETECNCLPS 479

Human   415 CNLTRYNKELSMVKIPSKT-----SAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAY 474
            |....|..|:|......||     |.:..|::..:....:|.    :.|||:...:.|..:.:.|
  Fly   480 CTSIAYEAEISQADFDYKTVINTDSPEGKEEQSKRQGMKMSR----VSIFFKEAQFLTSRRSELY 540

Human   475 EVAALLGDIGGQMGLFIGASILTILELFDYIY----ELI---------KEKLLDLLGKE 520
            .....|.:.||.:|||:|.|:|:|:||   ||    .||         :::||..:.|:
  Fly   541 GTTDFLANCGGLLGLFMGVSMLSIVEL---IYFCTVRLISNLRMRRKTRKELLKAVNKD 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	136/579 (23%)
ppk26	NP_648125.3	ASC	74..570	CDD:459966	130/551 (24%)