Protein Alignment ASIC2 and ppk27

DIOPT Version :10

• Sequence 1: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_647826.2
• Gene: ppk27 / 38440
• FlyBaseID: FBgn0035458
• Length: 422
• Species: Drosophila melanogaster
• Alignment Length: 483
• Identity: 101/483 - (20%)
• Similarity: 170/483 - (35%)
• Gaps: 167/483 - (34%)

Human    85 RRALWVLAFCTSFGLLLSWSS--NRLLYWLSFP-----SHTRVHREWSRQLPFPAVTVCNNNPLR 142
            :|..|.|..  |||:|.:..:  :.:|.:||:.     |..:|..:   ::.||.:.:|:.
  Fly    36 QRIFWFLFI--SFGILFASYAVFSMVLEFLSYSTIADLSELKVLED---EIHFPELKICSG---- 91

Human   143 FPRLSKGDLYYAGHWLGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGIS--- 204
                      |...:..:|   .:|..|||.   .::....|..||:     |...:|:.:|
  Fly    92 ----------YKFSYRNML---ASAHDLVSS---QNKSLDYWLNKLS-----LLSGYFDALSVKA 135

Human   205 ---------------AAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVFTKYGKCYMFNSGEDGK 254
                           ::|:..|....|.::|.||....   |.|...:||.  |.|     .||.
  Fly   136 ENVDDLNSLLDIKNISSFLLALTPACESLILKCKLNNI---PANCLKLFTL--KAY-----NDGN 190

Human   255 PLLTTVKGGTGNGLEIMLDIQQ-DEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPG 318
            ..:......||. |.:.:|..| ||| |:.|.                              .||
  Fly   191 CCVLRNSNLTGE-LTLFMDSSQIDEY-PLNGN------------------------------LPG 223

Human   319 FQTFVATQEQRLTYLPPPWGECRSSEM------GLDFFPVYSI--------------TACRIDCE 363
            |...|.:.:.|::..|   ||..:.|:      |......|::              ..|..:|.
  Fly   224 FSLHVPSWQGRVSINP---GEMAAVEIEVMELQGNSQLNEYAVEKRACYFSQEGESREKCLHECR 285

Human   364 TRYIVENCNCRMVHMPGD-----APFCTPEQHKECAEPALGLLAEKDSNYCLCRTP-----CN-- 416
            .:..:.||.|  |..|.:     ..:||.|..: |.:     |.|:  |:...:.|     ||
  Fly   286 IKATLINCQC--VPYPFEFRTQKFGYCTLENIR-CLQ-----LVER--NWSPAQCPQCLPLCNQL 340

Human   417 LTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLG 481
            ..|.||::.....|.::...:..|..:: ::| ..|||                   |....:|.
  Fly   341 FYRLNKQILGHLHPWRSELNFKFKTPHR-QRY-KTNIL-------------------YHWYQMLS 384

Human   482 DIGGQMGLFIGASILTILELFDYIYELI 509
            ::||.:|:.||.|.::..||   ||.|:
  Fly   385 NVGGVLGICIGCSFISGFEL---IYFLV 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	101/483 (21%)
ppk27	NP_647826.2	ASC	15..407	CDD:459966	99/479 (21%)