Protein Alignment ASIC2 and ppk29

DIOPT Version :10

• Sequence 1: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_001097442.2
• Gene: ppk29 / 37844
• FlyBaseID: FBgn0034965
• Length: 425
• Species: Drosophila melanogaster
• Alignment Length: 484
• Identity: 95/484 - (19%)
• Similarity: 169/484 - (34%)
• Gaps: 147/484 - (30%)

Human    88 LWVLAFCTSFGLLLSWSSNRLLYWLSFPSHT-----RVHREWSRQL-PFPAVTVC---------- 136
            ||:.....|     .||:..:|..|.....|     .|...:||.: .||::.:|
  Fly    23 LWIFVIGIS-----GWSTVSILVLLKTRYETDSTTIGVSTAYSRWINTFPSIGICLTKSRAFNEF 82

Human   137 ---------NNNPLRFPRLSKGDLY-YAGHWLGLLLPN---------RTARPLVSELLRGDEPRR 182
                     .:....|.|:    :| ||     .|.||         .|:.|....:|   :.||
  Fly    83 KAMMREYFQEDFAFSFTRM----IYEYA-----FLNPNNIFTKEPTKNTSYPYNFNIL---DIRR 135

Human   183 QWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGEL---CGPHNFSSVFTKYGKC 244
            :.|          |....|.....:                :||||   | ...|....|:.|.|
  Fly   136 KMF----------PTNCTECFKEIY----------------FRGELVTDC-EEIFKFHVTEMGYC 173

Human   245 YMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETT------FEAGV----KVQI 299
            ::.|:                     :||....|.:|:...:.:..      ..:.|    ::.:
  Fly   174 FLANN---------------------LLDYDSIEEMPLRYSSLDNNRSLRLYMRSSVMYKYEMYV 217

Human   300 HSQSEPPFIQELGFGVAPGFQTFVATQEQRLTY-----LPPPWGECR-SSEMGLDFFPVYSITAC 358
            :|..:.||...|.:.::....|:....|:...:     .|....:|: .||..::.|| ||.:||
  Fly   218 NSPEDLPFFNSLTYTISTDPTTYAFNVEEIHNHEGVIDEPISQRKCKFPSESSIEGFP-YSFSAC 281

Human   359 RIDCETRYIVENCNCRMVHMPGD---APFCTPEQHKECAEPALGLLAE----KDSNYCLCRTPCN 416
            .....:.:.::.|:|.:.: |.|   :.:| ..||.:|      |:.|    :...|....|.|.
  Fly   282 MSIIRSEFEMKTCDCSLFN-PKDRNESLYC-GLQHADC------LIKEGFATRVKEYVGSSTVCL 338

Human   417 LTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLG 481
            .:...:::|:|.:.::....|            :.|..:.:|...:......|:|.......|:.
  Fly   339 PSCVEQQISLVGVITENGTLY------------NNNTQITEIQIASPPTVRYERKVTQTKLDLIV 391

Human   482 DIGGQMGLFIGASILTILELFDYIYELIK 510
            .||...|||.|||:|.:||:..|..:.:|
  Fly   392 GIGSVAGLFFGASLLNLLEIISYFIKKLK 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	95/484 (20%)
ppk29	NP_001097442.2	ASC	8..415	CDD:459966	93/477 (19%)