Protein Alignment ASIC2 and ppk6

DIOPT Version :10

• Sequence 1: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_611461.3
• Gene: ppk6 / 37286
• FlyBaseID: FBgn0034489
• Length: 498
• Species: Drosophila melanogaster
• Alignment Length: 559
• Identity: 118/559 - (21%)
• Similarity: 191/559 - (34%)
• Gaps: 172/559 - (30%)

Human    44 GERALQGPGVARRGR-PSLSRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGL-LLSWSS- 105
            |::..:|.|..:||: |||.|..:.........||...|      :|::....::|| ...|||
  Fly    11 GKKNSKGDGSRKRGKDPSLIRTAILATFWEYTERTKVSG------MWLMRRNRTYGLSRFIWSSV 69

Human   106 ----------NRLLYWL---SFPSHTRVHREWS-RQLPFPAVTVCNNNPLRFPRLSKGDLYYAGH 156
                      ..||.||   |:|....:..:.| ..:.||.||:|:...:...|:   |.|..
  Fly    70 LLQLLLLSIYLTLLLWLKFYSYPILNTISNDLSITDVAFPGVTICSPKVVNSERV---DRYVK-- 129

Human   157 WLGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRH---------------------- 199
              .|.:|....   ::|::.|.:     |......:.|.||.|
  Fly   130 --TLKIPKEYD---MAEVIAGFD-----FLNAFTDQSFEPPGHDSYRATDAVLRLNNVSIWEAAM 184

Human   200 ------FEGISAAFMDRL------GHQLEDMLLSCKYRGELC----GPHNFSSVFTKYGKCYMFN 248
                  |:.:...|....      .|:....:.:..|.|..|    .|.|.|.|        .|:
  Fly   185 AVSPGCFDYVKRCFWGHTEFQCNQSHEYLSFIPTTAYLGPCCSFNYNPRNASFV--------PFS 241

Human   249 S---GEDGKPLLTTVKGGTGN---GLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPF 307
            :   |.||.......:|...|   ||.:::....| |:.          ||...|.|.:||| .|
  Fly   242 ANIFGMDGGLTFVGAEGSERNLNTGLIVLVHHPMD-YVT----------EAAASVTITAQSE-SF 294

Human   308 IQELGFGVAPGFQT----FVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIV 368
            ::     |:|..|:    .:...|::...|..  |:.:.|.        |...||.:.|:|..||
  Fly   295 VE-----VSPTVQSSSVEVLELSERKRDCLIS--GDLQLSN--------YRQAACLLACQTEAIV 344

Human   369 ENCNCRMVHMPGDAPFCTP---EQHKECAEPALGLLAEKDSNYCL--------------CRTPCN 416
            :.|.|.        |:..|   .:.|||         ..:..:|.              |...|.
  Fly   345 KKCGCH--------PYLLPIVGNKFKEC---------NLNDTFCYSANYDNFKSVRCDQCLPNCY 392

Human   417 LTRYNKELSMVKIPSKTSA---KYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAA 478
            ...|:      .:..||..   ||...:| .|.:.::.:..||.::........|.:........
  Fly   393 DVTYS------TLSYKTDLNQHKYSVSRF-YSPELLNNDSFVLRVYLAKQVVPVIRKVTVMSWIG 450

Human   479 LLGDIGGQMGLFIGASILTILELFDYI-------YELIK 510
            ||.|:||...|.:|.|:::::|.|.|.       |:|.|
  Fly   451 LLSDLGGIFNLCLGLSMISVVEFFYYCTYRLYINYQLQK 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	109/538 (20%)
ppk6	NP_611461.3	ASC	85..476	CDD:459966	94/464 (20%)