Protein Alignment ASIC2 and Nach

DIOPT Version :10

• Sequence 1: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_001334724.1
• Gene: Nach / 36864
• FlyBaseID: FBgn0024319
• Length: 553
• Species: Drosophila melanogaster
• Alignment Length: 538
• Identity: 104/538 - (19%)
• Similarity: 190/538 - (35%)
• Gaps: 155/538 - (28%)

Human    73 CAGRTAAGGSFQR--------RALWVLAFCTSFGLLLSWSSNRLLYWLSFPSHTRVHREWS--RQ 127
            ||..:..|..:.|        ..:|:|.....|...:..:....:.:.|.|:...|..:.:  .:
  Fly    31 CATSSIHGLKYTRDEDTNKIVHLVWLLISVVMFICAVVMARTFYMDYRSSPTRMNVESDNTPVNR 95

Human   128 LPFPAVTVCNN------------NPLRFPR-------LSKGDLYYAGHWLGLLLPNRTARPLVSE 173
            |.||.||:|.:            |.||.|:       |.|..::|     |.:|
  Fly    96 LYFPPVTICPDVLFNMQKSEAFLNTLRLPKGAELRGILRKLHIFY-----GFML----------- 144

Human   174 LLRGDEPR------RQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELCGPH 232
                |:.|      .|....|....|.:|         .|::.|....:::|..|::.||:.
  Fly   145 ----DDERYSAEDIEQMEALLFLNNLTIP---------EFVEHLRWNCDEILYRCRFNGEIM--- 193

Human   233 NFSSVF----TKYGKCYMFNSGEDG-----------------KPLLTTVK---GGTGNGLEIMLD 273
            :.|.:|    |.:|.|..||..:.|                 ..|..|.:   ||...||.:::.
  Fly   194 DCSKIFQLSKTFFGHCCSFNLRQKGWVNNKLNNLESFKVFHLNSLNFTAQRAIGGLRYGLSVVVR 258

Human   274 IQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWG 338
            .:.|.|.|:      .::..|||:.|......|........:|...:||.|.:.|. |:
  Fly   259 YKDDNYDPL------QSYSYGVKLLIQEADAFPSAHSAAKFIAFNSETFAAVRPQE-TF------ 310

Human   339 ECRS---------------SEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMP--------- 379
             |.|               :|..:.:|..|....|.::|....:|:.|.|......
  Fly   311 -CSSAVKALIIEERNCVFQNEFPMRYFSDYVYPNCELNCRVTNMVKFCGCHTYFFDFNRTSDRIC 374

Human   380 --GDAPFCTPEQHKE----CAE-------PALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPS 431
              .|.| |..:....    |::       .:..::..|.|..|.|...|....|:.:|:  ..|
  Fly   375 TFRDIP-CLVDNFGRLLLICSKYSDFNRLLSANIITRKKSTQCYCPLTCEHIDYDVQLT--NFP- 435

Human   432 KTSAKYLEKKFNKSEKY---ISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGA 493
                  ||.....::|:   :::|..||.:|..:.:|..:.:.....:..|:.::|....||:|.
  Fly   436 ------LELNMPVADKFYSGLAKNDGVLHVFINSFSYRRLRRDLLSNMVTLVSNLGSAFSLFVGM 494

Human   494 SILTILELFDYIYELIKE 511
            |:|:::|:..|...::::
  Fly   495 SMLSVVEIIYYFSVILRK 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	104/538 (19%)
Nach	NP_001334724.1	ASC	30..505	CDD:459966	103/529 (19%)