Protein Alignment ASIC2 and ppk14

DIOPT Version :10

• Sequence 1: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_609017.2
• Gene: ppk14 / 33887
• FlyBaseID: FBgn0031803
• Length: 504
• Species: Drosophila melanogaster
• Alignment Length: 528
• Identity: 106/528 - (20%)
• Similarity: 183/528 - (34%)
• Gaps: 165/528 - (31%)

Human    61 LSRAKLHGL---------RHMCAGRTAAGGSFQRRALWVLAF---CT-----SFGLLLSWSSNRL 108
            :||:.:|||         |.|             |.||.||.   ||     |: ||.....|:.
  Fly    46 ISRSHIHGLYLLFLPSMRRRM-------------RVLWALALICACTVLFHVSY-LLGDRYHNKQ 96

Human   109 LYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSE 173
            ...:...:|..:|     .:.||.|.:||.|.|.:.||                      |.:..
  Fly    97 FQTIVAHAHASIH-----HIAFPVVIICNKNRLNWSRL----------------------PEIKS 134

Human   174 LLRGDEPRRQWFRKLA------DFRLFLPPRHFEGISAAFMDRLGH------------QLEDMLL 220
            |......:.:.|.::.      .|..|   ..|:.:....:|.|.|            :.:::|.
  Fly   135 LYNITPSQDELFDRILTAYDGFSFHKF---NAFDSLLGESLDELNHLNFTEIVIQMSWRCDEILR 196

Human   221 SCKYRG------ELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEY 279
            .|.::.      :|..|...     ..|.|..||..|..:...|    |...||.:.|.:::.::
  Fly   197 DCHWQTASRDCCKLFRPRRL-----PLGYCLAFNELEKRRGTET----GINTGLLLRLLLREGQH 252

Human   280 LP-------IWGETEETTFEAGVKVQI--HSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPP 335
            .|       .|....|::...|..:::  ||::        ...|...:..|   .|..|: ||.
  Fly   253 APGNSGLKGFWLTVVESSVWFGFPIEVVPHSRT--------NVAVTAVYHYF---DESTLS-LPS 305

Human   336 PWGEC-RSSEMGLDFFPV-----YSITACRIDCETRYIVENCNCR--MVHMPGDAPFC------- 385
            .|..| ...|...:.|..     |.:..|:.:|:.||::..|||.  :.:.|.:.|.|
  Fly   306 SWRHCVMDYEEESEHFRTLEGQKYMLENCQAECQQRYLLRYCNCTVDLFYPPSNYPACRLKDLPC 370

Human   386 ------------TPEQHKECAEPALGLLAEKDSNYCL--CRTPCNLTRYNKELSMVKIPSKTSAK 436
                        .|.:|........||:.|     ||  |::...||...|.:....:...:||
  Fly   371 LAAHNHLLQNFEQPGEHPYVHREESGLVCE-----CLHNCKSLTLLTDMRKSVQQPWLQPNSSA- 429

Human   437 YLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILE- 500
             :|..:             |:::|:..:....:....|....|:...||...|.:|.||::::|
  Fly   430 -IESMW-------------LNVYFKKPSMLVYKTNLIYTWVDLIVSFGGICQLCLGCSIISLIEF 480

Human   501 LFDYIYEL 508
            :|..:|::
  Fly   481 VFFALYKV 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	104/525 (20%)
ppk14	NP_609017.2	ASC	45..483	CDD:459966	104/521 (20%)