Protein Alignment ASIC2 and ppk7

DIOPT Version :10

• Sequence 1: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_609016.2
• Gene: ppk7 / 33886
• FlyBaseID: FBgn0031802
• Length: 573
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 121/505 - (23%)
• Similarity: 195/505 - (38%)
• Gaps: 121/505 - (23%)

Human    63 RAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSF------GLLLSWSSNRLLYWLSFPSHTR-- 119
            |..:|||..:    .:|..|...|.:|:..|.::|      .|:||...| ..::.:....||
  Fly    41 RTTIHGLDRL----LSAKASRWERFVWLCTFVSAFLGAVYVCLILSARYN-AAHFQTVVDSTRFP 100

Human   120 VHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSELLRG--DEPRR 182
            |:|     :|||.:|:||.|.|.:.||::....:      |...:.:|:..:.||:.|  |:
  Fly   101 VYR-----IPFPVITICNRNRLNWQRLAEAKSRF------LANGSNSAQQELFELIVGTYDD--- 151

Human   183 QWFRKLADF-RLFLPPR---HFEGISAAFMDRLGHQLEDMLLSCKYRG---ELCGPHNFSSVFTK 240
            .:|.....| ||...|.   ::...|.. :|.:..:..::|..|.:|.   :.|  ..||...:|
  Fly   152 AYFGHFQSFERLRNQPTELLNYVNFSQV-VDFMTWRCNELLAECLWRHHAYDCC--EIFSKRRSK 213

Human   241 YGKCYMFNS--GEDGK------PLLTTVKGGTG--NGLEIMLDIQQDEYLPIWGETEETTFEAGV 295
            .|.|:.|||  .|:|:      |:.....|..|  :.|.:.:.||..::   |....||....|:
  Fly   214 NGLCWAFNSLETEEGRRMQLLDPMWPWRTGSAGPMSALSVRVLIQPAKH---WPGHRETNAMKGI 275

Human   296 KVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEM---------GLDFFP 351
            .|.:   :||.......|.||...:|.:..:.....|.....| .||.:.         ..||..
  Fly   276 DVMV---TEPFVWHNNPFFVAANTETTMEIEPVIYFYDNDTRG-VRSDQRQCVFDDEHNSKDFKS 336

Human   352 ----VYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKD------- 405
                ||.|..|:.:|...|:|..|||.|     |..| .|.|::.|....|..|||.:
  Fly   337 LQGYVYMIENCQSECHQEYLVRYCNCTM-----DLLF-PPGQYRSCRAQDLLCLAEHNDLLIYSH 395

Human   406 -------------SNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLD 457
                         ...|.|...|....|..::....:|              .:.|.:.:.:.||
  Fly   396 NPGEKEFVRNQFQGMSCKCFRNCYSLNYISDVRPAFLP--------------PDVYANNSYVDLD 446

Human   458 IFFEALNYETIEQKKAYEVAALLG------DIGGQMGLFIGASILTILEL 501
            :.|   .:|||   ..|..:.:.|      ..||..|||:|.|:::.:||
  Fly   447 VHF---RFETI---MVYRTSLVFGWVDLMVSFGGIAGLFLGCSLISGMEL 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	120/504 (24%)
ppk7	NP_609016.2	ASC	38..493	CDD:459966	121/505 (24%)