Protein Alignment ASIC2 and ppk13

DIOPT Version :10

• Sequence 1: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_001014495.1
• Gene: ppk13 / 3346226
• FlyBaseID: FBgn0053508
• Length: 460
• Species: Drosophila melanogaster
• Alignment Length: 496
• Identity: 118/496 - (23%)
• Similarity: 186/496 - (37%)
• Gaps: 122/496 - (24%)

Human    61 LSRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSSNRLLYWLSFPSHTR------ 119
            |..:.|||.|.:    .....|:..|..||:.      |:.||.::.||...|..:...
  Fly    11 LKNSTLHGARFI----VDKDASWIERIFWVIC------LVASWYASWLLIKASLSAFENNAISFV 65

Human   120 ---VHREWSRQLPFPAVTVC-NNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSEL--LRGD 178
               ..|:|:..  |||:.|| :.|..|...::: .|:.|.|       :.|...::||:  .||:
  Fly    66 VESSFRDWNTN--FPAIIVCESKNMDRIQEVAE-QLWGADH-------DFTLEEVLSEIAFFRGE 120

Human   179 EPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLE-------DMLLSCKYRG---ELCGPHN 233
                       .:.........|..::.|.....:..|       |.:.:|::..   |.|  ..
  Fly   121 -----------SYHTVHECSGEEVTASCFYSNFSYYAELVRSSCVDSISNCEWNNKPFECC--KY 172

Human   234 FSSVFTKYGKCYMFNSGEDGKPLLTTV----KGGTGNG-LEIMLDIQQDEYLPIWGETEETTFEA 293
            |..:.|:.|.||..||.:.|||.:..:    ..|:|.| |::.|            .||.|.|..
  Fly   173 FHRMETELGICYAINSMQAGKPKMPKLNMYSNRGSGPGALKMEL------------HTEATVFIL 225

Human   294 GVKVQIHSQSEPPFI-QELGFGVAPGFQTFVA---------TQEQRLTYLPPPWGECR-SSEMGL 347
            |      ::..|..: .:..|.|...:.:||.         .:|.|.|.:..  ..|| :.|..|
  Fly   226 G------TEEVPTLVTPKTDFLVVGPYISFVRYISKRDIENDEEIRQTSVHQ--RNCRFADENIL 282

Human   348 DFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAP---FCTPEQHKECAEPALGLLAEKDSNYC 409
            |....||.:||.:.|.....:|.|||.. |:..::|   .|..|          ||       .|
  Fly   283 DVHKFYSYSACTVQCRKDRQMELCNCSS-HLSPNSPDWQLCNME----------GL-------EC 329

Human   410 LCRTPCNLT---------RYNKELSMVKIPSKTSAKYLEKKFNKSEKYISEN-ILVLDIFFEALN 464
            |.|...:|:         |..|.|....:||.|.........:|.....|:| |..:::....|.
  Fly   330 LNRNYEDLSVIIAKWSKLRGRKGLVCDCLPSCTEVDITTVYDSKENMAGSQNAISRIEVGLIELP 394

Human   465 YETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYI 505
            .|..::........|:..|||..|||:|||:|:.:|:|.||
  Fly   395 TERYKRNLVRGKLDLVVSIGGTTGLFVGASLLSFVEIFYYI 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	117/493 (24%)
ppk13	NP_001014495.1	ASC	10..434	CDD:459966	116/493 (24%)