Protein Alignment ASIC2 and ppk23

DIOPT Version :10

• Sequence 1: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_001097011.1
• Gene: ppk23 / 32731
• FlyBaseID: FBgn0030844
• Length: 591
• Species: Drosophila melanogaster
• Alignment Length: 588
• Identity: 131/588 - (22%)
• Similarity: 221/588 - (37%)
• Gaps: 164/588 - (27%)

Human    45 ERALQGPGVARRG-----RPSLSRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFC-TSFG----L 99
            :|.|:...:.||.     :.....:.|||:|::.......|..|    :|   || ||.|    |
  Fly    14 QRFLETLVIFRRSLIYQTKEFFQNSTLHGVRYIAESGRPIGEKF----MW---FCFTSIGAVTAL 71

Human   100 LLSWSSNRLLYWLSF---PSHTRVHREWSRQ-LPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGL 160
            ::..|     .|..|   |:.|.:..::..| :.||...||       |..:      ..|
  Fly    72 VIIMS-----LWEKFQTNPTITGLDTDFHNQNVVFPTTVVC-------PEAA------FDH---- 114

Human   161 LLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGI------SAAFMDRL-------- 211
               ::|...:.:.|...||.:.|.:   ..|...|...:||.:      |.:....|
  Fly   115 ---DKTYEKVYNTLANYDEAQAQMY---TPFLRILTSLNFENVRDAKVLSQSIPQNLLDAHTIRE 173

Human   212 ----GH-QLEDMLLSCKYRGE--LCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLE 269
                || ..:::.:|||||.|  .|..| |..::|::|.||.|||.....| ...||.|..:.|
  Fly   174 WAFEGHIDCKNVFVSCKYRDEDIPCCDH-FEPIYTEHGFCYAFNSRFKSTP-TEDVKTGAPHDL- 235

Human   270 IMLDIQQDE-----YLP-----IWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVA 324
                .:.|:     ::|     |:..:.|..|.:....|| ..|||..::     |....:....
  Fly   236 ----YETDKKWALFFIPNSTSRIFIFSNEEYFGSDFNAQI-DWSEPQLVE-----VRISKKNTYT 290

Human   325 TQEQRLTYLPPPWGECR---SSEMGLDFFP-VYSITACRIDCETRYIVENCNCRMVHMPGDAPFC 385
            |.:.|...:    |:.:   |.|:.|::|| .|:.::|...|.....::.|.|       :.||.
  Fly   291 TDDARQLSI----GQRKCIFSDEVKLNYFPDAYTFSSCMKQCRMNKAIKLCKC-------NPPFY 344

Human   386 TPEQHKECA------------------EPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSK 432
            .|.:...|.                  :..:.:.:.||.: ||.....|:|.. |:....::...
  Fly   345 KPIRELSCVINIFTNLIAYILLLYLTPKANVPMCSIKDFD-CLDEFKSNITNI-KDCLQCELSCS 407

Human   433 TSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEV----AALLGDIGGQMGLFIGA 493
            .:...::|....|::..|..:||     |.|.:..|..|:  ||    ..||...||...||:|.
  Fly   408 KTVFNIDKLIKMSDRPESLGVLV-----EFLTWPIIRYKR--EVLFGWVDLLVSFGGIASLFLGF 465

Human   494 SILTILELFDY---------------IYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHSETI 543
            |:|:.:|:..|               :|| |:||:     ::|.....|..:|    :.:|:..|
  Fly   466 SLLSGVEIIYYFTLRACCMVYKNRQELYE-IEEKI-----RQEPPPKIDLKLS----LKSHNPRI 520

Human   544 SHT 546
            ..|
  Fly   521 GDT 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	127/564 (23%)
ppk23	NP_001097011.1	ASC	34..476	CDD:459966	115/509 (23%)