Protein Alignment ASIC2 and ppk22

DIOPT Version :10

• Sequence 1: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_733051.2
• Gene: ppk22 / 318593
• FlyBaseID: FBgn0051105
• Length: 561
• Species: Drosophila melanogaster
• Alignment Length: 528
• Identity: 116/528 - (21%)
• Similarity: 192/528 - (36%)
• Gaps: 133/528 - (25%)

Human    85 RRALWVLA-FCTSFGLLLSWSSNRLLYWLSFPSHTRVHREWS-----RQLPFPAVTVCNNNPLRF 143
            :|.:|:|. ..|:..|::..|    |.|..|.:.:.|.....     ..:|||||::|.||
  Fly    65 QRLIWLLVHMATTVSLIVVLS----LTWEQFVAQSFVTNLKDPLFPVENVPFPAVSICPNN---- 121

Human   144 PRLSK-GDLYYAGHWLGLLLPNRTARPLVSELLRGDEPRRQWFRK-------------LADFRLF 194
             |:|: ..:.||..   |.|.:...||:...|     .|.::||:             ...|:.|
  Fly   122 -RISRQAVIQYAEE---LRLNSPVIRPVEYFL-----ERLRFFREFYTHVGVVVDTDDFITFQTF 177

Human   195 LP-------PRHFEGISAAFMDRLGHQLEDMLLSCKYRG---ELCGPHNFSSVFTKYGKCYMFNS 249
            |.       ...|:  :...|..|..:.:..:|.|....   .......|....|.||.|..||.
  Fly   178 LDVFGTWNNETFFD--TRRIMKMLTPRCQGFVLKCTVANVEVPCFSKDAFQDSLTMYGPCCTFNM 240

Human   250 GEDGKPLLTTVKGGTGN---GLEIML-DIQQDEYLPIW-----------GETEETTFEAGVKVQI 299
              :.|......|....:   ||:::| |...|.:.||.           .|...:.:.:.|....
  Fly   241 --ENKLKKRHFKNRLASSELGLKVVLNDSHVDYFAPILNTNGYIVMIHNAENYASVYSSNVLEMF 303

Human   300 HSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLP------------PPWGECRSSEMGLDF-FP 351
            ..|.|..:|....        ..|.|.:...::.|            .|..|...:...|.: ||
  Fly   304 PGQGEDSYIAVCA--------RVVDTDDSLKSFSPFSRRCYFEYEAQNPIHEQLMNTYSLSYTFP 360

Human   352 VYSITACRIDCETRYIVENCNCRMVHMP-------GDAPFCTPEQHKECAEPAL----GLLAEK- 404
             ..||.|||    |.|:..|.|....||       ....:|| ..|..|....:    .:|.|:
  Fly   361 -NCITRCRI----RSIIALCRCLPFQMPLQLVENLDGVVYCT-LGHVSCLNQYIFKWRNILTERH 419

Human   405 ----------DSNYC-LCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDI 458
                      ::.|| .|...|...:|...:|.:.|.:..:...|::. |::|  ...:|.||.:
  Fly   420 IVNGLEREIEEALYCPQCLPSCRDVQYEVSMSALPIDNYLATLKLDEN-NETE--FGTDISVLRV 481

Human   459 FF---EALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELF----DYIYE----LIKEK 512
            :|   .|..|..:.....:||.:.:|:|   |.:|:|.|::.|.|:.    .|||:    ::::.
  Fly   482 YFGDPHAQYYIRLLNNTWFEVFSTIGNI---MSIFVGFSMVAIFEILFFVTKYIYKGCNRMVEQN 543

Human   513 LLDLLGKE 520
            ::|...||
  Fly   544 IMDRKAKE 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	116/528 (22%)
ppk22	NP_733051.2	ASC	46..527	CDD:459966	110/502 (22%)