Protein Alignment ASIC2 and ppk31

DIOPT Version :10

• Sequence 1: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_001097944.1
• Gene: ppk31 / 318575
• FlyBaseID: FBgn0051065
• Length: 421
• Species: Drosophila melanogaster
• Alignment Length: 468
• Identity: 107/468 - (22%)
• Similarity: 166/468 - (35%)
• Gaps: 164/468 - (35%)

Human    96 SFGLLLSWSSNRLLYWLSFPSHTRVHREWSRQLPFPAVTVCN-NNPLRFPRLSKGDLYYAGHWLG 159
            |..||.|:.|:.    :||...| ::..|:.  .|||:|||. .|..|...||..: :...|
  Fly    21 SLSLLNSYLSSS----VSFNLDT-IYLNWNS--TFPAITVCEIYNAERIWDLSDSN-FGVEH--- 74

Human   160 LLLPNRTARPLVSELLRGDEPRRQWFRKLA----DFRLFLPPRHFEGISAAFMDRLGHQLEDMLL 220
                :......:||::        ::|.:.    |......|.:|..:...|..:. |||   |:
  Fly    75 ----DMHVDDFISEIV--------FYRGVCSSCEDCSRMRCPSNFTHLVDVFRTKC-HQL---LV 123

Human   221 SCKYRGEL---CGPHNFSSVFTKYGKCYMFNSGEDGK--PLLTTVKGGTGNG---LEIMLDIQQD 277
            :|.|..:|   |  ..|..:.|:||.|:.|||.:..|  .|..|....||.|   .....|||..
  Fly   124 NCTYLNKLFDCC--DQFLPLPTEYGLCFSFNSHQARKVSHLQFTNNRMTGPGHLSFHAAADIQLY 186

Human   278 EYLPI-------WGETEETTFEAGVK------VQIHSQSEPPFIQELGFGVAPGFQTFVATQEQR 329
            .:.||       .|...||......|      :::|:...   :|:|             :.|||
  Fly   187 VHAPIDVPYQFSEGMIRETVLLGHYKELILNVIEVHNDES---VQDL-------------SMEQR 235

Human   330 LTYLPPPWGECR------SSEMGL-DFFPVYSITACRIDCETRYIVENCNC--RMVHMPGD--AP 383
                     .||      ....|: ||   ||.:.|.::|.....::||||  ..:.:||.  .|
  Fly   236 ---------RCRYGHEHVPERQGIYDF---YSYSGCVVECTVLLQLDNCNCTSHFMAIPGQNYLP 288

Human   384 FC--------TPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYN-------------KELS-- 425
            .|        |..:.|        ::.|:.|  |.|.:.|....||             .|:|
  Fly   289 VCDVRGLICLTRIRDK--------IMTERKS--CECMSSCEEPEYNIIYNSADEDDEASDEVSEI 343

Human   426 ---MVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQM 487
               :|::|::...:.:.|             .:||                     .|..:||.:
  Fly   344 RVALVELPTQRYVRRVTK-------------TILD---------------------FLISLGGLV 374

Human   488 GLFIGASILTILE 500
            |||...|.|.|:|
  Fly   375 GLFFNTSALRIVE 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	107/468 (23%)
ppk31	NP_001097944.1	ASC	36..387	CDD:459966	99/447 (22%)