Protein Alignment ASIC2 and ppk8

DIOPT Version :10

• Sequence 1: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_001036260.3
• Gene: ppk8 / 318213
• FlyBaseID: FBgn0052792
• Length: 569
• Species: Drosophila melanogaster
• Alignment Length: 607
• Identity: 124/607 - (20%)
• Similarity: 219/607 - (36%)
• Gaps: 176/607 - (28%)

Human    55 RRGRPS------------LSR--------AKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGL 99
            :|.||.            |||        ..:|||:::...:..:..    |..:.:|......|
  Fly    17 KRSRPQHLQITLSTWRRILSRNTDEFCRNTTIHGLKYINNSKLRSSD----RLFFGIALLVVLSL 77

Human   100 LL--------SWSSNRLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPL---RFPRLSKGDLYY 153
            .:        .|::|.::..:. |..|.:..|     ||||||:||.|..   |....|...:.:
  Fly    78 AIYLIQDAFDKWNTNPVIVGID-PELTSIANE-----PFPAVTICNLNQALAERVEHFSNDSVEF 136

Human   154 AGHWLGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDM 218
            |      :|.....|.:..||::.::.|  |                    ..|:..:......|
  Fly   137 A------MLQLLCRRKVDVELVKTNDSR--W--------------------EEFILNISQPCNSM 173

Human   219 LLSCKYRGE--LCGPHNFSSVFTKYGKCYMFNS-------------------------------- 249
            ::.|::..:  .|. ..|..:.|..|.|.:||.
  Fly   174 VIHCRFGADDYECA-RLFHPIVTDEGLCCVFNMLHPRFMYRKRVPYSHRNISLPEGFHAVNWHAE 237

Human   250 --------GEDG-KPLLTTVKGGTGN--GLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQS 303
                    ..|| .||......|||.  ||.:.||:|.|.|..      .::...|.|:.:||.:
  Fly   238 LGYRKRGFQPDGDNPLYPRRAQGTGESLGLSLTLDVQADAYYC------SSSSSIGFKIALHSPN 296

Human   304 EPPFIQELGFGVAPGFQTFVATQ------EQRLTYLPPPWGECR-SSEMGLDFFPVYSITACRID 361
            |.|.::|.|..:|||.:|.:...      |:.|..:......|. .:|:.|.:|..|:...|..:
  Fly   297 ESPNVRETGVLLAPGMETKLRIDPSKILTEKHLRNVDRRSRRCLFHNELKLRWFAHYTQRNCVAE 361

Human   362 CETRYIVENCNCRMVHMP---GDAPFCTPEQHKECAEPALGLLAEKD---SNYCL--CRTPC--- 415
            |.:.:::.:|.|...:||   .:...| |...:||.|    |:..:.   ...||  |...|
  Fly   362 CLSGWLIRHCGCVTFYMPRLNANDTIC-PLHKRECVE----LIRFRTIIAMESCLDECLPSCFDL 421

Human   416 --NLTRYNKELSM---VKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYE 475
              :...|:..:|:   .:.||...       :|.::.|:..::.|::::|:...:...:|.:...
  Fly   422 SFSAIAYSTRISLDGFRETPSNGG-------WNFTDAYVERSVAVVNMYFKDPTFRANKQTEFIG 479

Human   476 VAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHS 540
            .:..|..:||.||||:|.|.|:|.|.  ..:.||:.                  ..||..:...:
  Fly   480 FSDFLSGVGGLMGLFLGFSFLSIAEC--VYFALIRP------------------CRTCSEIRQLN 524

Human   541 ETISHTVNVPLQTTLGTLEEIA 562
            :...|.:|:....|.|.:..|:
  Fly   525 QPRVHQMNLKRSPTPGNIRYIS 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	114/561 (20%)
ppk8	NP_001036260.3	ASC	42..508	CDD:459966	109/524 (21%)