Protein Alignment ASIC2 and ppk3

DIOPT Version :10

• Sequence 1: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_726336.1
• Gene: ppk3 / 246504
• FlyBaseID: FBgn0050181
• Length: 535
• Species: Drosophila melanogaster
• Alignment Length: 570
• Identity: 125/570 - (21%)
• Similarity: 197/570 - (34%)
• Gaps: 143/570 - (25%)

Human    39 GGGR--GGERALQGPGVARRGRPSLSRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLL 101
            |.||  |..|.:.....|..|..:||         :|..|:.   ....|..|:....:|....|
  Fly    31 GCGRLFGRLRDVVAQAGAETGLLALS---------LCVNRSI---HLLERLFWLAVVVSSVIAAL 83

Human   102 SWSSNRLLYWLSFP---SHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSK------------GDL 151
            ..|..:|..:.|.|   |..|.:|.|:..|  ||||:|..:.:...:.::            .|.
  Fly    84 VLSRLQLERYFSSPTVISVDRDYRGWNGSL--PAVTLCYYDHIDSFKANEYIQEMWNVSIIDEDY 146

Human   152 YYAGHWLGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLF-LPPRHFEGISAAFMDRLGHQL 215
            :|...:|..:: |.||.. .:||.:..|..|  |.::..:.:. ...|.||.:.::|  ..|.|:
  Fly   147 FYFMDFLYAVV-NATAGN-YAELAKFAEDER--FDQIDLYEMIQRVDRPFEQVISSF--DAGFQV 205

Human   216 EDMLLSCKYRGELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLD------- 273
                             :...|.|:.|.||..||.      ::||..|.....|:|..
  Fly   206 -----------------HVQRVMTERGACYAINSP------MSTVLSGQPVAYELMPQPLSCQYG 247

Human   274 -----IQQDEY-----LPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQ 328
                 |:.|.|     |.:....|.:..||.: |.:|...|          :...|:.......:
  Fly   248 KQQCYIRMDLYESTGVLDVHSPFEVSATEANI-VALHKSDE----------ITASFKVLETVASK 301

Human   329 RLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMP-GDAPFCTPEQHKE 392
            .|..|.....:|..:........:||.:.|...|.....:|.|||.....| .|.|.|.|... |
  Fly   302 NLRQLSVAQRKCVFNNEETSNLKIYSKSLCLARCRAVMALEMCNCVPFFYPYVDGPSCNPAGF-E 365

Human   393 CAEPALGLLAEKDSNYCL--CRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILV 455
            |      ||..|...:.|  |:.|...|.....:..|| .|....|      |..|...||...
  Fly   366 C------LLDFKWPIWALHICKCPSTCTEIEYTMQTVK-KSSWGVK------NNEEVASSETAT- 416

Human   456 LDIFFEALNYETIEQK------KAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLL 514
                 .:..::.|..|      ..|....|:...||.:.||:|.|::.::|:   ::.|:...||
  Fly   417 -----SSFRWDLIPPKVRMRRDVVYSFEDLVVSFGGVLALFVGVSVMGLVEM---VHVLVNNLLL 473

Human   515 D-------LLG------KEED---EGSHDENVSTCDTMPNHSETISHTVN 548
            |       :||      :.:|   |.:|..:.:.      |:....|..|
  Fly   474 DVFTLLRLMLGRLRRCWRRDDHMREANHHHHANA------HAHARLHDFN 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	115/540 (21%)
ppk3	NP_726336.1	ASC	59..464	CDD:459966	103/472 (22%)