DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eip75B and Thra

DIOPT Version :9

Sequence 1:	NP_001246821.1	Gene:	Eip75B / 39999	FlyBaseID:	FBgn0000568	Length:	1412	Species:	Drosophila melanogaster
Sequence 2:	NP_112396.2	Gene:	Thra / 81812	RGDID:	3857	Length:	492	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	144/547 - (26%)
Similarity:	233/547 - (42%)	Gaps:	100/547 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   411 PPKVKHASSSSSGNSSSSNTNNSSSSSNGEEP-----SSSIPD-LEFDGTTVLCRVCGDKASGFH 469
            |.||:  ..|....:|:.:.:......||:.|     |..||. |:.|..   |.||||||:|:|
  Rat     5 PSKVE--CGSDPEENSARSPDGKRKRKNGQCPLKSSMSGYIPSYLDKDEQ---CVVCGDKATGYH 64

  Fly   470 YGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSIL-RINRNRCQYCRLKKCIAVGMSRDAV--RF 531
            |...:||||||||||:||:.:......|...|.:: :|.||:||.||.||||||||:.|.|  ..
  Rat    65 YRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDS 129

  Fly   532 GRVPKREKARILAAMQQSTQNRGQQ---RALATELDDQPR---LLAAVLRAHLETCEFTKEKVSA 590
            .||.||:      .::|:.:.|.::   |:|....:..|.   |:.....||    ..|..:.|.
  Rat   130 KRVAKRK------LIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHVATEAH----RSTNAQGSH 184

  Fly   591 MRQRARDCP-SYSMPTLLACPLNPAPELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFT 654
            .:||.:..| ......:::.|.....:|::..||::.....|..|:|||..:|.|..|..:|:..
  Rat   185 WKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQII 249

  Fly   655 LLKAGLFDALFVRLICMFDSSINSIICLNGQVMRRDAIQNGANARFLVDSTFNFAERMNSMNLTD 719
            |||....:.:.:|....:|...:::.......::|:.::|| ....:.|:.|...:.:::.||.|
  Rat   250 LLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNG-GLGVVSDAIFELGKSLSAFNLDD 313

  Fly   720 AEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTLS 784
            .|:.|..|::|::.||.||..::.|||.........::.|...:.:.|.|..|||  |.:....|
  Rat   314 TEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLL--MKEREVQS 376

  Fly   785 TLHTEKLVVFRTEHKELLRQQMWSMEDGNNSDGQQNKS----PSGSWADAM------DVEAAKSP 839
            ::                      :..|..::|:...|    |.|.....|      .|...:..
  Rat   377 SI----------------------LYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQ 419

  Fly   840 LGSVSSTESADLDYGSPSSSQPQGVSLPSPPQQQPSALASSAPLL-------------AATLSGG 891
            .|...|.....|.:.||.|           |||:...|...:.:|             |::||
  Rat   420 FGEAGSLRGPVLQHQSPKS-----------PQQRLLELLHRSGILHSRAVCGEDDSSEASSLS-- 471

  Fly   892 CPLRNRANSGSSGDSGAAEMDIVGSHA 918
                   :|.|..|:...| |:.|..|
  Rat   472 -------SSSSDEDTEVCE-DLAGKAA 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	45/90 (50%)
Eip75B	NP_001246821.1	NR_LBD_REV_ERB	609..796	CDD:132738	45/186 (24%)
Thra	NP_112396.2	Modulating	1..52		13/48 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		7/29 (24%)
		NR_DBD_TR	52..138	CDD:143519	45/94 (48%)
		NR_LBD_TR	162..370	CDD:132733	52/214 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..492		10/44 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010