Protein Alignment Eip75B and VDR

DIOPT Version :9

• Sequence 1: NP_001246821.1
• Gene: Eip75B / 39999
• FlyBaseID: FBgn0000568
• Length: 1412
• Species: Drosophila melanogaster
• Sequence 2: NP_001351014.1
• Gene: VDR / 7421
• HGNCID: 12679
• Length: 494
• Species: Homo sapiens
• Alignment Length: 513
• Identity: 146/513 - (28%)
• Similarity: 229/513 - (44%)
• Gaps: 112/513 - (21%)

  Fly   443 SSSIPDL-EFD-GTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILR 505
            |:|:||. :|| ....:|.||||:|:|||:...:|||||||||||:::|..: .|..|..|.|.:
Human     7 STSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALF-TCPFNGDCRITK 70

  Fly   506 INRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQQSTQNRGQQRALATEL-----DD 565
            .||..||.||||:|:.:||.::.:......:|::..||        .|.::.||...|     ::
Human    71 DNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIL--------KRKEEEALKDSLRPKLSEE 127

  Fly   566 QPRLLAAVLRAHLET--------CEFTKE-KVS------AMRQRARDCPSYSMPTLLAC------ 609
            |.|::|.:|.||.:|        |:|... :|:      ..|..:|..||:|..:..:|
Human   128 QQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCIT 192

  Fly   610 -------------------PLNPAPELQSEQ-----EFSQRFAHVIRGVIDFAGMIPGFQLLTQD 650
                               ..:|:..|:..|     ..:...::.|:.||.||.|||||:.||.:
Human   193 SSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSE 257

  Fly   651 DKFTLLKAGLFDALFVRLICMFDSSINSIICLNGQVMRR--DAIQNGANARFLVDSTFNFAERMN 713
            |:..|||:...:.:.:|....|.....|..|.|.....|  |..:.|.:.. |::....|...:.
Human   258 DQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLE-LIEPLIKFQVGLK 321

  Fly   714 SMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQ-YIVAQNRPDQPEFL-AKLLET 776
            .:||.:.|..|..||.:::|||||:::..|||.:..||...|| ||..::.|.....| ||:::.
Human   322 KLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQK 386

  Fly   777 MPDLRTLSTLHTEKLVVFRTEHKELLRQQMWSME--------DGNNSD--GQQNKSPSGSWADAM 831
            :.|||:|:..|::       :::.|..|...||:        .||...  ||....|  .|.
Human   387 LADLRSLNEEHSK-------QYRCLSFQPECSMKLTPLVLEVFGNEISXLGQPVAVP--GWG--- 439

  Fly   832 DVEAAKSPLGSVSSTESADLDYGSPSSSQPQGVSLPSPPQQQPSALASSAPLLAATLS 889
                                 ..|.::.|.:|..|.|.|   |..:..|||.|...||
Human   440 ---------------------CSSRATCQARGWRLLSSP---PHPVWGSAPPLPPPLS 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	37/87 (43%)
		NR_LBD_REV_ERB	609..796	CDD:132738	59/220 (27%)
VDR	NP_001351014.1	NR_DBD_VDR	16..122	CDD:143513	45/114 (39%)
		Hinge	97..126		7/36 (19%)
		NR_LBD_VDR	124..426	CDD:132731	80/309 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..190		7/31 (23%)
		Vitamin D3 binding	227..237		0/9 (0%)
		Vitamin D3 binding	271..278		1/6 (17%)
		9aaTAD. /evidence=ECO:0000269|PubMed:30468856	416..424		0/7 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910