Protein Alignment Eip75B and THRB

DIOPT Version :9

• Sequence 1: NP_001246821.1
• Gene: Eip75B / 39999
• FlyBaseID: FBgn0000568
• Length: 1412
• Species: Drosophila melanogaster
• Sequence 2: NP_000452.2
• Gene: THRB / 7068
• HGNCID: 11799
• Length: 461
• Species: Homo sapiens
• Alignment Length: 437
• Identity: 129/437 - (29%)
• Similarity: 209/437 - (47%)
• Gaps: 55/437 - (12%)

  Fly   387 HQQQQQQQQSSLGNSVMRPPPPPPPPKVKHASSSSSGNSSSSNTNNSSSSS----NGEEPSSS-- 445
            |::...:::|:|.|.      ...|..::...:||..:....:.|:.|.||    ..||....
Human    38 HRKSHSERRSTLKNE------QSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGY 96

  Fly   446 IPD-LEFDGTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKI--QYRPCTKNQQCSILRIN 507
            ||. |:.|   .||.||||||:|:||...:||||||||||:||:.:  .| .|....:|.|.::.
Human    97 IPSYLDKD---ELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSY-SCKYEGKCVIDKVT 157

  Fly   508 RNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQQSTQNRGQQRALATEL--------- 563
            ||:||.||.||||.|||:.|.|       .:.::.||..:...:||.::|  ..||
Human   158 RNQCQECRFKKCIYVGMATDLV-------LDDSKRLAKRKLIEENREKRR--REELQKSIGHKPE 213

  Fly   564 --DDQPRLLAAVLRAHLETCEFTKEKVSAMRQRARDCPSYSMPTLLACPLNPAPE-----LQSEQ 621
              |::..|:..|..||:.    |..:.|..:|:.:..|.    .:...|:..|||     |::..
Human   214 PTDEEWELIKTVTEAHVA----TNAQGSHWKQKRKFLPE----DIGQAPIVNAPEGGKVDLEAFS 270

  Fly   622 EFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLICMFDSSINSIICLNGQV 686
            .|::.....|..|:|||..:|.|..|..:|:..|||....:.:.:|....:|.. :..:.|||::
Human   271 HFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPE-SETLTLNGEM 334

  Fly   687 -MRRDAIQNGANARFLVDSTFNFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMYSR 750
             :.|..::|| ....:.|:.|:....::|.||.|.|:.|..|::|::.|||||..:|.|||....
Human   335 AVTRGQLKNG-GLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDS 398

  Fly   751 LKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTLSTLHTEKLVVFRTE 797
            .....::.:...:.....|..|||..:.|||.:...|..:.:..:.|
Human   399 FLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVE 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	42/89 (47%)
		NR_LBD_REV_ERB	609..796	CDD:132738	53/192 (28%)
THRB	NP_000452.2	Modulating	1..106		17/76 (22%)
		NR_DBD_TR	106..192	CDD:143519	44/93 (47%)
		NR_LBD_TR	216..458	CDD:132733	63/240 (26%)
		Interaction with NR2F6. /evidence=ECO:0000269|PubMed:10713182	244..461		55/208 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010