Protein Alignment Eip75B and THRA

DIOPT Version :9

• Sequence 1: NP_001246821.1
• Gene: Eip75B / 39999
• FlyBaseID: FBgn0000568
• Length: 1412
• Species: Drosophila melanogaster
• Sequence 2: NP_001177848.1
• Gene: THRA / 7067
• HGNCID: 11796
• Length: 490
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 144/538 - (26%)
• Similarity: 235/538 - (43%)
• Gaps: 84/538 - (15%)

  Fly   411 PPKV-------KHASSSSSGNSSSSNTNNS-SSSSNGEEPSSSIPDLEFDGTTVLCRVCGDKASG 467
            |.||       ::::.|..|.....|...| .:|.:|..||....|.:       |.||||||:|
Human     5 PSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQ-------CVVCGDKATG 62

  Fly   468 FHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSIL-RINRNRCQYCRLKKCIAVGMSRDAV-- 529
            :||...:||||||||||:||:.:......|...|.:: :|.||:||.||.||||||||:.|.|
Human    63 YHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLD 127

  Fly   530 RFGRVPKREKARILAAMQQSTQNRGQQ---RALATELDDQPR---LLAAVLRAHLETCEFTKEKV 588
            ...||.||:      .::|:.:.|.::   |:|....:..|.   |:.....||    ..|..:.
Human   128 DSKRVAKRK------LIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAH----RSTNAQG 182

  Fly   589 SAMRQRARDCP-SYSMPTLLACPLNPAPELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDK 652
            |..:||.:..| ......:::.|.....:|::..||::.....|..|:|||..:|.|..|..:|:
Human   183 SHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQ 247

  Fly   653 FTLLKAGLFDALFVRLICMFDSSINSIICLNGQVMRRDAIQNGANARFLVDSTFNFAERMNSMNL 717
            ..|||....:.:.:|....:|...:::.......::|:.::|| ....:.|:.|...:.:::.||
Human   248 IILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNG-GLGVVSDAIFELGKSLSAFNL 311

  Fly   718 TDAEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMPDLRT 782
            .|.|:.|..|::|::.||.||..::.|||.........::.|...:.:.|.|..|||  |.:...
Human   312 DDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLL--MKEREV 374

  Fly   783 LSTLHTEKLVVFRTEHKELLRQQMWSMEDGNNSDGQQNKS----PSGSWADAM------DVEAAK 837
            .|::                      :..|..::|:...|    |.|.....|      .|...:
Human   375 QSSI----------------------LYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLE 417

  Fly   838 SPLGSVSSTESADLDYGSPSSSQPQGVSLPSPPQQQPSALASSAPLLAATLSGGCPLRNRANSGS 902
            ..||...|.:...|.:.||.|           |||:...|...:.:|.|....|....:.|:|.|
Human   418 QQLGEAGSLQGPVLQHQSPKS-----------PQQRLLELLHRSGILHARAVCGEDDSSEADSPS 471

  Fly   903 SGDSGAAEM--DIVGSHA 918
            |.:. ..|:  |:.|:.|
Human   472 SSEE-EPEVCEDLAGNAA 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	45/90 (50%)
		NR_LBD_REV_ERB	609..796	CDD:132738	45/186 (24%)
THRA	NP_001177848.1	Modulating	1..52		12/46 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32		6/26 (23%)
		NR_DBD_TR	52..138	CDD:143519	45/98 (46%)
		NR_LBD_TR	162..370	CDD:132733	52/214 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	457..490		9/33 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010