Protein Alignment Eip75B and RARB

DIOPT Version :9

• Sequence 1: NP_001246821.1
• Gene: Eip75B / 39999
• FlyBaseID: FBgn0000568
• Length: 1412
• Species: Drosophila melanogaster
• Sequence 2: NP_001277145.1
• Gene: RARB / 5915
• HGNCID: 9865
• Length: 455
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 159/525 - (30%)
• Similarity: 236/525 - (44%)
• Gaps: 102/525 - (19%)

  Fly   366 SSSSHIFRTPVVSSSSSSNMHHQQQQQQQQSSLGNSVMRPPP---PP-------PPPKVKHASSS 420
            ::|.|....|.|    :.:|.|..             ..|.|   ||       ||....|....
Human     2 TTSGHACPVPAV----NGHMTHYP-------------ATPYPLLFPPVIGGLSLPPLHGLHGHPP 49

  Fly   421 SSGNSSSSNTNNSSSSSNGEE----PSSSIPDLEFDGTTVLCRVCGDKASGFHYGVHSCEGCKGF 481
            .||.|:.|.....:.|::.||    |.|.:|.   ......|.||.||:||:||||.:|||||||
Human    50 PSGCSTPSPATIETQSTSSEELVPSPPSPLPP---PRVYKPCFVCQDKSSGYHYGVSACEGCKGF 111

  Fly   482 FRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAM 546
            ||||||:.:.| .|.:::.|.|.::.|||||||||:||..||||:::||..|..|::
Human   112 FRRSIQKNMIY-TCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKK-------- 167

  Fly   547 QQSTQNRGQQRALATELDDQPRLLAAVLRAHLET----CEFTKEKV-SAMRQRARDCPSYSMPTL 606
            :.|.|...:...:..||||   |...:.:||.||    |:..|... |:...|.|
Human   168 ETSKQECTESYEMTAELDD---LTEKIRKAHQETFPSLCQLGKYTTNSSADHRVR---------- 219

  Fly   607 LACPLNPAPELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLICM 671
                    .:|....:||:.....|..:::||..:|||..||..|:.|||||...|.|.:|:...
Human   220 --------LDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTR 276

  Fly   672 FDSSINSIICLNGQVMRRDAIQNGANARF--LVDSTFNFAERMNSMNLTDAEIGLFCAIVLITPD 734
            :....:::...:|..:.|..:.   ||.|  |.|..|.||.::..:.:.|.|.||..||.||..|
Human   277 YTPEQDTMTFSDGLTLNRTQMH---NAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGD 338

  Fly   735 RPGLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTLSTLHTEKLVVFRTE-- 797
            |..|.....::|:...|...|:..:.:.||.:|....|:|..:.|||::|....|:::..:.|
Human   339 RQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIP 403

  Fly   798 --HKELLRQQMWSMEDGNNSDGQQNKSPSGSWADAMDVEAAKSPLGSVSSTESADLDYGSPSSSQ 860
              ...|:::.:      .||:|.:..:||.|     ...|..||  |:           ||||.:
Human   404 GSMPPLIQEML------ENSEGHEPLTPSSS-----GNTAEHSP--SI-----------SPSSVE 444

  Fly   861 PQGVS 865
            ..|||
Human   445 NSGVS 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	47/87 (54%)
		NR_LBD_REV_ERB	609..796	CDD:132738	54/188 (29%)
RARB	NP_001277145.1	Modulating	1..87		23/104 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	47..78		8/30 (27%)
		NR_DBD_RAR	82..166	CDD:143522	46/84 (55%)
		Hinge	154..182		7/35 (20%)
		NR_LBD_RAR	186..416	CDD:132735	67/259 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..455		17/53 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010