Protein Alignment Eip75B and RARA

DIOPT Version :9

• Sequence 1: NP_001246821.1
• Gene: Eip75B / 39999
• FlyBaseID: FBgn0000568
• Length: 1412
• Species: Drosophila melanogaster
• Sequence 2: XP_005257609.1
• Gene: RARA / 5914
• HGNCID: 9864
• Length: 478
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 150/521 - (28%)
• Similarity: 230/521 - (44%)
• Gaps: 112/521 - (21%)

  Fly   358 SSAIGSGGSSSSHIFRTPVVSSSSSSNMHHQQQQQQQQSSLGNSVMRPPPPPPPPKVKHASSSSS 422
            |:..|:||.:....:|...|:.|:.         :.|.||....|..||.|||.|::
Human    53 SAGQGAGGRAPRAGWRAGDVTGSAI---------ETQSSSSEEIVPSPPSPPPLPRI-------- 100

  Fly   423 GNSSSSNTNNSSSSSNGEEPSSSIPDLEFDGTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQ 487
                             .:|               |.||.||:||:||||.:|||||||||||||
Human   101 -----------------YKP---------------CFVCQDKSSGYHYGVSACEGCKGFFRRSIQ 133

  Fly   488 QKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGR------VPKREKARILAAM 546
            :.:.| .|.:::.|.|.::.|||||||||:||..||||:::||..|      |||.|.:
Human   134 KNMVY-TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECS------ 191

  Fly   547 QQSTQNRGQQRALATELDDQPRLLAAVLRAHLET----CEFTKEKV-SAMRQRARDCPSYSMPTL 606
                    :...|..|:.:   |:..|.:||.||    |:..|... ::..||.
Human   192 --------ESYTLTPEVGE---LIEKVRKAHQETFPALCQLGKYTTNNSSEQRV----------- 234

  Fly   607 LACPLNPAPELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLICM 671
                   :.::....:||:.....|...::||..:|||..||..|:.|||||...|.|.:|:...
Human   235 -------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTR 292

  Fly   672 FDSSINSIICLNGQVMRRDAIQNGANARF--LVDSTFNFAERMNSMNLTDAEIGLFCAIVLITPD 734
            :....:::...:|..:.|..:.   ||.|  |.|..|.||.::..:.:.|||.||..||.||..|
Human   293 YTPEQDTMTFSDGLTLNRTQMH---NAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGD 354

  Fly   735 RPGLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTLSTLHTEKLVVFRTE-- 797
            |..|...:.::.:...|...|:..|.:.||.:|....|:|..:.|||::|....|:::..:.|
Human   355 RQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIP 419

  Fly   798 --HKELLRQQMWSMEDGNNSDGQQNKSPSGSWADAMDVEAAKSPLGSVSSTESADLDYGSPSSSQ 860
              ...|:::.:.:.|..:...||    |.|...|.   .....|.||.|.:.|...:..||::..
Human   420 GSMPPLIQEMLENSEGLDTLSGQ----PGGGGRDG---GGLAPPPGSCSPSLSPSSNRSSPATHS 477

  Fly   861 P 861
            |
Human   478 P 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	50/93 (54%)
		NR_LBD_REV_ERB	609..796	CDD:132738	54/188 (29%)
RARA	XP_005257609.1	NR_DBD_RAR	98..182	CDD:143522	48/124 (39%)
		NR_LBD_RAR	202..432	CDD:132735	66/253 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010