DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip75B and vdrb

DIOPT Version :9

Sequence 1:	NP_001246821.1	Gene:	Eip75B / 39999	FlyBaseID:	FBgn0000568	Length:	1412	Species:	Drosophila melanogaster
Sequence 2:	NP_001153457.1	Gene:	vdrb / 564511	ZFINID:	ZDB-GENE-080403-10	Length:	422	Species:	Danio rerio

Alignment Length:	405	Identity:	115/405 - (28%)
Similarity:	193/405 - (47%)	Gaps:	56/405 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   443 SSSIPDLEFD-GTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRI 506
            |:.:|| ||| ....:|.||||||:|||:...:|||||||||||:::|..: .|..|..|:|.:.
Zfish     8 STQVPD-EFDRNVPRICGVCGDKATGFHFNAMTCEGCKGFFRRSMKRKASF-TCPFNGSCTITKD 70

  Fly   507 NRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQQSTQNRGQQRALATELDDQPRLLA 571
            ||..||.||||:|:.:||.::.:......:|:|..|.....:......|:..|:   |:|..::.
Zfish    71 NRRHCQACRLKRCLDIGMMKEFILTDEEVQRKKELIQRRKDEEAHREAQKPRLS---DEQRNIID 132

  Fly   572 AVLRAHLETCEFTKEKVSAMRQRARDCP--------------------SYS-----------MPT 605
            .::.||.:|.:.:....|..|...|:.|                    |:|           :..
Zfish   133 TLVDAHHKTYDDSYSDFSRFRPPVREGPVTRSASRAASLHSLSDASSDSFSHSPESGDRKMNLSN 197

  Fly   606 LLAC----PLNPAPELQSEQ--------EFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKA 658
            ||..    .|:.:|:.:.|.        ..:...::.|:.||.||.|||||:.||.:|:..|||:
Zfish   198 LLMMYQEQGLSSSPDSKEEDGSSLSMLPHLADLVSYSIQKVIGFAKMIPGFRELTAEDQIALLKS 262

  Fly   659 GLFDALFVRLICMFDSSINSIICLNGQVMR---RDAIQNGANARFLVDSTFNFAERMNSMNLTDA 720
            ...:.:.:|....|.....|..| .|...:   .|..:.|.... |::....|...:..:||.:.
Zfish   263 SAIEVIMLRSNQSFSLEDMSWSC-GGPEFKYCVNDVTKAGHTLE-LLEPLVKFQVGLKKLNLHEE 325

  Fly   721 EIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTLST 785
            |..|..||.|::|||||:::...:|.:..::...||..:..:.|......||:::.:.|||:|:.
Zfish   326 EHVLLMAICLLSPDRPGVQDHVRVEALQDKVSEVLQAYIRAHHPGGRLLYAKMIQKLADLRSLNE 390

  Fly   786 LHTE--KLVVFRTEH 798
            .|::  :.:.|:.||
Zfish   391 EHSKQYRSLSFQPEH 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	39/87 (45%)
Eip75B	NP_001246821.1	NR_LBD_REV_ERB	609..796	CDD:132738	52/203 (26%)
vdrb	NP_001153457.1	NR_DBD_VDR	15..121	CDD:143513	43/106 (41%)
		Hinge	96..125		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	106..128		4/24 (17%)
		NR_LBD	123..421	CDD:299703	68/288 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..190		6/44 (14%)
		Vitamin D3 binding. /evidence=ECO:0000250	224..234		0/9 (0%)
		Interaction with coactivator LXXLL motif. /evidence=ECO:0000250	243..261		9/17 (53%)
		Vitamin D3 binding. /evidence=ECO:0000250	268..275		1/6 (17%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P11473	411..419
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910