DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip75B and nr1d4a

DIOPT Version :9

Sequence 1:	NP_001246821.1	Gene:	Eip75B / 39999	FlyBaseID:	FBgn0000568	Length:	1412	Species:	Drosophila melanogaster
Sequence 2:	XP_021325494.1	Gene:	nr1d4a / 563150	ZFINID:	ZDB-GENE-080403-5	Length:	572	Species:	Danio rerio

Alignment Length:	581	Identity:	191/581 - (32%)
Similarity:	264/581 - (45%)	Gaps:	169/581 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 GSGGSSSSHIFRTPVVSSSSSSNMHHQQQQQQQQSSLGNSVMRPPPPPPPPKVKHASSSSSGNSS 426
            ||.||||      |...|.||.        .|.||...:|  :|..|......:..:....||:.
Zfish    15 GSSGSSS------PSPGSPSSG--------YQTQSPSSHS--QPSSPEEVTFTEIGAFKQQGNAG 63

  Fly   427 SSNT-----------NNSSSSSN---------GEEPSSSIPDLEFDGT-------TVLCRVCGDK 464
            |.|:           |||::..|         |:.|..      |.||       .:||:||||.
Zfish    64 SPNSPKLVFQFPEIYNNSTAGPNPHSYSHPIAGKRPCG------FTGTFTKTGGMVLLCKVCGDI 122

  Fly   465 ASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAV 529
            |||||||||:||||||||||||||.|.|:.|.||:.|.|:|:||||||:||.|||::||||||||
Zfish   123 ASGFHYGVHACEGCKGFFRRSIQQNINYKMCVKNENCLIMRMNRNRCQHCRFKKCLSVGMSRDAV 187

  Fly   530 RFGRVPKREKARILAAMQQSTQNRGQQRALATELDDQ------------PRLLAAVLRAHLETCE 582
            ||||:|||||.|:|..| ||..|...:.::..|...|            ...:.|:.||:.:...
Zfish   188 RFGRIPKREKQRLLDEM-QSYMNSLNESSMGMETSPQHEPPPSPIENQSKEAIGALSRAYQDIFT 251

  Fly   583 FTKEKV-------------SAMRQRARD----------------------------------CP- 599
            .|::.:             |.....::|                                  ||
Zfish   252 NTQDHLNKRAGNNNISRSSSYQNSPSQDSNYPHANPLAGYHTTTHESFSGPVRCPVSTSESKCPV 316

  Fly   600 --------SY----------------SMPT---------------------------LLACPLN- 612
                    ||                |.||                           :||||||
Zfish   317 SLVDNNRYSYAPSFSQNHSQSSVNQPSQPTQAHYSSYTASQSQSPASCPFKLAAGSKVLACPLNA 381

  Fly   613 ---PAPELQSEQ---EFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLICM 671
               .||.:.|:|   .|||.|...:|.|::||..|||||.|.|.|:..|||||.|..|.||...:
Zfish   382 CPVSAPGVSSQQVWESFSQCFTPAVREVVEFAKGIPGFQELCQHDQVMLLKAGTFQVLMVRFCSL 446

  Fly   672 FDSSINSIICLNGQVMRRDAIQNGANARFLVDSTFNFAERMNSMNLTDAEIGLFCAIVLITPDRP 736
            |:....|:..||||......:: |.....|:|:.|.|:.:::|:.|...|:.||.|:||::.|..
Zfish   447 FNHKERSVTFLNGQTYPLGTLR-GLGMGSLLDAMFEFSSKLSSLGLESDEMALFMAVVLVSADCS 510

  Fly   737 GLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTLSTLHTEKLVVFRTE 797
            |:.::..:|::...|...|:.::.:..||.....:|||..:||||||:.||::||:.||.:
Zfish   511 GISDMLAVEQLQEGLIRALRTLINRRHPDDNSLFSKLLLRLPDLRTLNNLHSDKLLAFRID 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	67/94 (71%)
Eip75B	NP_001246821.1	NR_LBD_REV_ERB	609..796	CDD:132738	73/193 (38%)
nr1d4a	XP_021325494.1	NR_DBD_REV_ERB	111..199	CDD:143540	65/87 (75%)
nr1d4a	XP_021325494.1	NR_LBD	382..570	CDD:325017	69/188 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5003
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002268
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1497
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.970