DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip75B and pparab

DIOPT Version :9

Sequence 1:	NP_001246821.1	Gene:	Eip75B / 39999	FlyBaseID:	FBgn0000568	Length:	1412	Species:	Drosophila melanogaster
Sequence 2:	NP_001096037.1	Gene:	pparab / 557714	ZFINID:	ZDB-GENE-990415-211	Length:	459	Species:	Danio rerio

Alignment Length:	461	Identity:	146/461 - (31%)
Similarity:	221/461 - (47%)	Gaps:	71/461 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 RPPPPPPPPKVKHA--------------SSSSSGNSSSSNTNNSSSSSNGEEPSSSIPDL----- 449
            |||.|.....:..|              |......||...|.|.|...:|.|.|:.:..|
Zfish     9 RPPSPLDDSVLDSALFVRGMEELRDISQSMDEDALSSFEMTENQSGLGSGSESSTELDALTPASS 73

  Fly   450 -------------EFDGTT--VLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQ 499
                         ||..|:  :.||||.|:|||:|||||:||||||||||:|:.|::|..|  .:
Zfish    74 PSSGVYGCPVGQDEFTSTSLNLECRVCSDRASGYHYGVHACEGCKGFFRRTIRLKLEYDKC--ER 136

  Fly   500 QCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQQSTQNRGQQRALATELD 564
            :|.|.:.|||:|||||.:||::||||.:|:||||:|:.||.|:.|.:  .|..|..:       |
Zfish   137 RCKIQKKNRNKCQYCRFQKCLSVGMSHNAIRFGRMPQSEKLRLKAEI--LTGERDVE-------D 192

  Fly   565 DQPRLLAAVLRAHLETCEFTKEKVSAMRQRARDCPSY---SMPTLL------------ACP--LN 612
            ||..|...:..|:::.....|.|...:.......|.:   .|.||.            :|.  ||
Zfish   193 DQKTLAKQIYEAYVKNFNMNKSKARTILTGKTSTPPFVIHDMETLQLAEQTFVAKMMGSCGGLLN 257

  Fly   613 PAPELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLI-CMFDSSI 676
            ..||::............:..:.:||..:|||..|..:|:.||||.|:.:|||..|. ||....:
Zfish   258 KDPEVRIFHCCQCTSVETVTELTEFAKSVPGFSNLDLNDQVTLLKYGVHEALFAMLASCMNKDGL 322

  Fly   677 NSIICLNGQVMRRDAIQNGANARF--LVDSTFNFAERMNSMNLTDAEIGLFCAIVLITPDRPGLR 739
              ::......:.|:.::: ....|  :::..|.||.:.||:.|.|:::.||.|.::...|||||.
Zfish   323 --LVAYGSGFITREFLKS-LRRPFSDMMEPKFQFAMKFNSLELDDSDLALFVAAIICCGDRPGLV 384

  Fly   740 NLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTLSTLHTEKL-VVFRTEHKEL-- 801
            |:..||:|...:...|...:..|.||......|||:.:.|||.|.|.|.:.: .:.:||...|
Zfish   385 NVPHIERMQESIVNVLHLHLKSNHPDHGFLFPKLLQKLVDLRQLVTEHAQLIQEIKKTEDTSLHP 449

  Fly   802 LRQQMW 807
            |.|:::
Zfish   450 LLQEIY 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	52/89 (58%)
Eip75B	NP_001246821.1	NR_LBD_REV_ERB	609..796	CDD:132738	57/192 (30%)
pparab	NP_001096037.1	NR_DBD_Ppar	96..179	CDD:143523	51/84 (61%)
		C4 zinc finger; ZnF_C4	97..161		40/65 (62%)
		NR_LBD_PPAR	193..458	CDD:132730	72/266 (27%)
		ligand binding domain of hormone receptors (HOLI)	279..429		49/152 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26498
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.010