DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip75B and rarab

DIOPT Version :9

Sequence 1:	NP_001246821.1	Gene:	Eip75B / 39999	FlyBaseID:	FBgn0000568	Length:	1412	Species:	Drosophila melanogaster
Sequence 2:	XP_005164086.1	Gene:	rarab / 555364	ZFINID:	ZDB-GENE-980526-72	Length:	460	Species:	Danio rerio

Alignment Length:	512	Identity:	150/512 - (29%)
Similarity:	227/512 - (44%)	Gaps:	100/512 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 GGSSSSHIFRTPVVSSSSSSNMHHQQQQQQQQSSLGNSVMRPPPPPPPPKVKHASSSSSGNSSSS 428
            ||.|...:...||...|:.|    ....:.|.:|....|..||.|||||:|
Zfish    35 GGLSPPALPGLPVSGYSTPS----PATVETQSTSSEEIVPSPPSPPPPPRV-------------- 81

  Fly   429 NTNNSSSSSNGEEPSSSIPDLEFDGTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYR 493
                       .:|               |.||.||:||:||||.:|||||||||||||:.:.|
Zfish    82 -----------YKP---------------CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVY- 119

  Fly   494 PCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQQSTQNRGQQRA 558
            .|.:.:.|.|.::.|||||||||:||:.||||:::||..| .||:|            :..:|..
Zfish   120 TCHREKSCIINKVTRNRCQYCRLQKCLEVGMSKESVRNDR-NKRKK------------DDKKQEC 171

  Fly   559 LATEL--DDQPRLLAAVLRAHLET----CEFTKEKV--SAMRQRARDCPSYSMPTLLACPLNPAP 615
            |...:  .|..:::..|.:||.||    |:..|...  ||..:.|.|...:
Zfish   172 LENYVLSPDTEKMIEQVRKAHQETFPSLCQLGKYTTNNSADHRVALDVDLW-------------- 222

  Fly   616 ELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLICMFDSSINSII 680
                 .:||:.....|...::||..:|||..||..|:.|||||...|.|.:|:...:....:::.
Zfish   223 -----DKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPDQDTMT 282

  Fly   681 CLNGQVMRRDAIQNGANARF--LVDSTFNFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNLEL 743
            ..:|..:.|..:.   ||.|  |.|..|.||.::..:.:.|||.||..||.|:..||..|...:.
Zfish   283 FSDGLTLNRTQMH---NAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLLCGDRQDLEQSDK 344

  Fly   744 IEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTLSTLHTEKLVVFRTE----HKELLRQ 804
            ::::...|...|:..|...||.:|....|:|..:.|||::|....|:::..:.|    ...|:::
Zfish   345 VDELQEPLLEALKIYVRNRRPHKPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQE 409

  Fly   805 QMWSMEDGNNSDGQQNKSPSGSWADAMDVEAAKSPLGSVSSTESADLDYGSPSSSQP 861
            .:      .||:|.:.....|:...........:|.||.|.:.|....:.|||:..|
Zfish   410 ML------ENSEGLEGGGSKGAGGGGGGGGGKGAPPGSCSPSLSPSSAHSSPSAHSP 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	49/87 (56%)
Eip75B	NP_001246821.1	NR_LBD_REV_ERB	609..796	CDD:132738	53/188 (28%)
rarab	XP_005164086.1	NR_DBD_RAR	80..155	CDD:143522	45/115 (39%)
rarab	XP_005164086.1	NR_LBD_RAR	184..413	CDD:132735	66/256 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010