Protein Alignment Eip75B and PPARA

DIOPT Version :9

• Sequence 1: NP_001246821.1
• Gene: Eip75B / 39999
• FlyBaseID: FBgn0000568
• Length: 1412
• Species: Drosophila melanogaster
• Sequence 2: NP_001001928.1
• Gene: PPARA / 5465
• HGNCID: 9232
• Length: 468
• Species: Homo sapiens
• Alignment Length: 410
• Identity: 141/410 - (34%)
• Similarity: 213/410 - (51%)
• Gaps: 64/410 - (15%)

  Fly   421 SSGNSSSSNTNNSSSSSNGEEPSSSIPDLEFDGTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRS 485
            |..:|.||.|......|..|.||.::        .:.||:|||||||:|||||:||||||||||:
Human    73 SPASSPSSVTYPVVPGSVDESPSGAL--------NIECRICGDKASGYHYGVHACEGCKGFFRRT 129

  Fly   486 IQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAM---Q 547
            |:.|:.|..|  ::.|.|.:.|||:|||||..||::||||.:|:||||:|:.|||::.|.:   :
Human   130 IRLKLVYDKC--DRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCE 192

  Fly   548 QSTQNRGQQRALATELDDQPRLLAAVLRAHLETCEFTKEKVSA---MRQRARDCPSY---SMPTL 606
            ...::        :|..|...|...:..|:|:  .|...||.|   :..:|.:.|.:   .|.||
Human   193 HDIED--------SETADLKSLAKRIYEAYLK--NFNMNKVKARVILSGKASNNPPFVIHDMETL 247

  Fly   607 LACPLNPAPELQS----EQEFSQRFAH--------VIRGVIDFAGMIPGFQLLTQDDKFTLLKAG 659
            .........:|.:    .:|...|..|        .:..:.:||..||||..|..:|:.||||.|
Human   248 CMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYG 312

  Fly   660 LFDALFVRLICMFDSSINSIICLNGQVMRRDAIQNGANAR-FL----------VDSTFNFAERMN 713
            :::|:|..|        :|::..:|.::   |..||...| ||          ::..|:||.:.|
Human   313 VYEAIFAML--------SSVMNKDGMLV---AYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFN 366

  Fly   714 SMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMP 778
            ::.|.|::|.||.|.::...|||||.|:..||||...:...|:..:..|.||......|||:.|.
Human   367 ALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMA 431

  Fly   779 DLRTLSTLHTEKL-VVFRTE 797
            |||.|.|.|.:.: ::.:||
Human   432 DLRQLVTEHAQLVQIIKKTE 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	52/87 (60%)
		NR_LBD_REV_ERB	609..796	CDD:132738	62/210 (30%)
PPARA	NP_001001928.1	NR_DBD_Ppar	101..184	CDD:143523	53/84 (63%)
		NR_LBD_PPAR	201..467	CDD:132730	77/264 (29%)
		Required for heterodimerization with RXRA	304..433		45/139 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40886
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4550
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.040