Protein Alignment Eip75B and nr1d1

DIOPT Version :9

• Sequence 1: NP_001246821.1
• Gene: Eip75B / 39999
• FlyBaseID: FBgn0000568
• Length: 1412
• Species: Drosophila melanogaster
• Sequence 2: NP_991292.2
• Gene: nr1d1 / 494487
• ZFINID: ZDB-GENE-050105-1
• Length: 637
• Species: Danio rerio
• Alignment Length: 627
• Identity: 193/627 - (30%)
• Similarity: 279/627 - (44%)
• Gaps: 200/627 - (31%)

  Fly   359 SAIGSGGSSSSHIFRTPVVSSSSSSNMHHQQQQQQQQSSLGNSVMRPPPPPPPPKVKHAS----- 418
            |.|||.|.|.:......:.|.:|:|:|     |...|...|:|.      ||.|...|.|
Zfish    22 SYIGSCGGSPNRTSPVSMYSENSNSSM-----QSLTQPCFGSSF------PPSPNGSHDSSRMYT 75

  Fly   419 SSSSGNSSSSNTNNSSSSSNG------------EEPSSSIPDL-EFDGTTVLCRVCGDKASGFHY 470
            ||||.:||.|..:.:||.|.|            ..|:.|:..| :.:|..:||:||||.||||||
Zfish    76 SSSSSSSSGSGEDGNSSCSGGSPRGRDDGGSARNSPNKSVATLTKLNGMVLLCKVCGDVASGFHY 140

  Fly   471 GVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVP 535
            |||:||||||||||||||.|||:.|.||:.|:|:||||||||.||.|||::||||||||||||:|
Zfish   141 GVHACEGCKGFFRRSIQQNIQYKKCLKNETCTIMRINRNRCQQCRFKKCLSVGMSRDAVRFGRIP 205

  Fly   536 KREKARILAAMQQS--------TQNRGQQRALAT------------------------------- 561
            ||||.|:||.||.:        .||..|..::.:
Zfish   206 KREKQRMLAEMQNAMNNMVNNQLQNEFQLASITSNTPCPSSSSPSNTSSSSSSPCPGLTVGPQPQ 270

  Fly   562 --------------------ELDDQP----------------RLLAAVLRAHLETCEFTKEKVSA 590
                                :|...|                :.:||:.|||.||..:..:|:.:
Zfish   271 PPAVPVAQSPSSPAPTSPTVQLAQSPPPLTSTPPPCTSPGVDKTIAAITRAHRETFIYAHDKLGS 335

  Fly   591 ----------------------------------------------------------------- 590
                                                                             
Zfish   336 PLLPHNSELDNRSNNRCMAGYHLNGHNTIYHHDNNVAHHCNNFEVQQDNSLHFQASQTPEKHQQH 400

  Fly   591 ----------------------MRQRARDCP-SYSMPTLLACPLNPAPELQSE-------QEFSQ 625
                                  ...:.::|| ......|||||:|..|.....       ::||.
Zfish   401 NNNSQRPPNSNFYSIHHGQEMNSASQGQNCPWKKHKEILLACPMNMHPYSDPNKTPQEIWEDFSL 465

  Fly   626 RFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLICMFDSSINSIICLNGQVMRRD 690
            .|...:|.|::||..||||..|:|:|:.||||||.|:.|.||...:|:....::..::|.....:
Zfish   466 SFTPAVREVVEFAKHIPGFSTLSQNDQVTLLKAGTFEVLMVRFSSLFNVKEKTVTFISGATYSLE 530

  Fly   691 AIQNGANARFLVDSTFNFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCL 755
            |::: .....|:.:.|:|:|::||:.|:..|:|||.|:||::.||.|:.|:..:|.:...|...|
Zfish   531 ALKS-MGMGDLLGTMFDFSEKLNSLELSAEELGLFTAVVLVSADRSGIENVNSVEMLQESLIRAL 594

  Fly   756 QYIVAQNRPDQPEFLAKLLETMPDLRTLSTLHTEKLVVFRTE 797
            :.:|:::.|.......|||..:||||||:.:|:|||:.||.:
Zfish   595 RTLVSKSAPTDASRFTKLLLKLPDLRTLNNMHSEKLLSFRID 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	68/87 (78%)
		NR_LBD_REV_ERB	609..796	CDD:132738	68/193 (35%)
nr1d1	NP_991292.2	NR_DBD_REV_ERB	123..211	CDD:143540	68/87 (78%)
		NR_LBD_REV_ERB	448..635	CDD:132738	65/187 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5003
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002268
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1497
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.970