DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip75B and Nr1d2

DIOPT Version :9

Sequence 1:	NP_001246821.1	Gene:	Eip75B / 39999	FlyBaseID:	FBgn0000568	Length:	1412	Species:	Drosophila melanogaster
Sequence 2:	NP_035714.3	Gene:	Nr1d2 / 353187	MGIID:	2449205	Length:	576	Species:	Mus musculus

Alignment Length:	586	Identity:	190/586 - (32%)
Similarity:	270/586 - (46%)	Gaps:	158/586 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 VIASVSSSSSSSAIGS----GGSSSSHIFRTPVVSSSSSSNMHHQQQQQQQQSSLGNSVMRPPPP 408
            |||.:|||||:|:..|    |..:|.....:.|.||.:|||.......:....|..:.|::....
Mouse     8 VIAYISSSSSASSPASCHSEGSENSFQSSSSSVPSSPNSSNCDANGNPKNADISSIDGVLKSDRT 72

  Fly   409 PPPPKVKHASSSSSGNSSSSNTNNSSSSSNGEEPSSSIPDLEFDGTTVLCRVCGDKASGFHYGVH 473
            ..|.|....|:.....|.|..|                   :|.|..:||:||||.|||||||||
Mouse    73 DCPVKTGKTSAPGMTKSHSGMT-------------------KFSGMVLLCKVCGDVASGFHYGVH 118

  Fly   474 SCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKRE 538
            :||||||||||||||.|||:.|.||:.|||:|:||||||.||.|||::||||||||||||:||||
Mouse   119 ACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKRE 183

  Fly   539 KARILAAMQ------QSTQNRGQ-QRALATELDDQPRLLAAVL---RAHLE-------TCEFTKE 586
            |.|:|..||      .:||..|. |.....|..||..|.|...   ::.||       ..:|.||
Mouse   184 KQRMLIEMQSAMKTMMNTQFSGHLQNDTLAEQHDQSALPAQEQLRPKSQLEQENIKNTPSDFAKE 248

  Fly   587 KVSAMRQRA-----------RDCPSYSMPTL---------------------------------- 606
            :|..|..||           |:..|.|||..
Mouse   249 EVIGMVTRAHKDTFLYNQEHRENSSESMPPQRGERIPRNMEQYNLNQDHRGSGIHNHFPCSERQQ 313

  Fly   607 ----------------------------------------------------------------- 606

Mouse   314 HLSGQYKGRNIMHYPNGHAVCIANGHCMNFSSAYTQRVCDRIPVGGCSQTENRNSYLCNTGGRMH 378

  Fly   607 LACPLNPAPELQSE-------QEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDAL 664
            |.||::.:|.:..:       :|||..|...::.|::||..||||:.|:|.|:..|||||.|:.|
Mouse   379 LVCPMSKSPYVDPQKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVL 443

  Fly   665 FVRLICMFDSSINSIICLNGQVMRRDAIQNGANARFLVDSTFNFAERMNSMNLTDAEIGLFCAIV 729
            .||...:||:...::..|:|:....|.: :...|..|:.|.|.|:|::|::.|:|.|:.||.|:|
Mouse   444 MVRFASLFDAKERTVTFLSGKKYSVDDL-HSMGAGDLLSSMFEFSEKLNALQLSDEEMSLFTAVV 507

  Fly   730 LITPDRPGLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTLSTLHTEKLVVF 794
            |::.||.|:.|:..:|.:...|...|:.::.:|.|::.....|||..:||||:|:.:|:|:|:.|
Mouse   508 LVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAF 572

  Fly   795 R 795
            :
Mouse   573 K 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	68/87 (78%)
Eip75B	NP_001246821.1	NR_LBD_REV_ERB	609..796	CDD:132738	67/194 (35%)
Nr1d2	NP_035714.3	Modulating	1..99		27/109 (25%)
		Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000269\|PubMed:29533925	1..60		18/51 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..90		20/76 (26%)
		NR_DBD_REV_ERB	98..186	CDD:143540	68/87 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..246		6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..282		5/18 (28%)
		NR_LBD_REV_ERB	386..574	CDD:132738	65/189 (34%)
		Interaction with ZNHIT1. /evidence=ECO:0000250	394..576		64/181 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	132	1.000	Domainoid score	I5084
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002268
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1497
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.970