DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eip75B and Hr4

DIOPT Version :9

Sequence 1:	NP_001246821.1	Gene:	Eip75B / 39999	FlyBaseID:	FBgn0000568	Length:	1412	Species:	Drosophila melanogaster
Sequence 2:	NP_001259161.1	Gene:	Hr4 / 31162	FlyBaseID:	FBgn0264562	Length:	2123	Species:	Drosophila melanogaster

Alignment Length:	1942	Identity:	400/1942 - (20%)
Similarity:	625/1942 - (32%)	Gaps:	714/1942 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EAVQAAAAATSSG-----------GSSGSVPGSGSGSASKLIKTE-PIDFEMLHLEENERQQDIE 54
            :||.|||||.::|           .|....|.|.|.::|...:.| ..|.|.....|.||.:|.|
  Fly   360 KAVAAAAAAAAAGHVTVLVTPSRIKSEPPPPASPSSTSSTQRERERERDRERDRERERERDRDRE 424

  Fly    55 REPSSSNSNSNS-----NSLTPQRYTHVQ-----VQTVPPRQPTGLTTPGGTQKVILTPRVEYV- 108
            ||...|.|:|..     ::..|.:.:|..     |||....|.  ||.|...:|  .:|..|::
  Fly   425 REREQSISSSQQHLSRVSASPPTQLSHGSLGPNIVQTHHLHQQ--LTQPLTLRK--SSPPTEHLL 485

  Fly   109 ---QQRATSSTGGGMKHVYSQQQGTAASRSAPPE-------TTALLTTTSGTPQIIITRTLPSNQ 163
               .|..|......:.|:..|||  ...:::.|:       :...|......|.:       ..:
  Fly   486 SQSMQHLTQQQAIHLHHLLGQQQ--QQQQASHPQQQQQQQHSPHSLVRVKKEPNV-------GQR 541

  Fly   164 HLSRRHSASPSALHHYQQQQPQRQQSPPPLHHQQQQQQQHVRVIRDGRLYDEATVV--------- 219
            |||..|......|.|:||||.|:||....||.||||||.|.:..:...|...|::.
  Fly   542 HLSPHHQQQSPLLQHHQQQQQQQQQQQQHLHQQQQQQQHHQQQPQALALMHPASLALRNSNRDAA 606

  Fly   220 ----VAARRHSVSPPPLHHHSRSAPVSPVIARRGGAAA--------------------------- 253
                |.:..|......|.|..:||         |||||
  Fly   607 ILFRVKSEVHQQVAAGLPHLMQSA---------GGAAAAAAAAVAAQRMVCFSNARINGVKPEVI 662

  Fly   254 --------------------------YMDQQYQQRQTPPLAPPPPPPPPPP-------------- 278
                                      :........|..|..|...||...|
  Fly   663 GGPLGNLRPVGVGGGNGSGSVQCPSPHPSSSSSSSQLSPQTPSQTPPRGTPTVIMGESCGVRTMV 727

  Fly   279 ----PPPP---------PQQQQQQYISTGVPPPTAAARKFVVSTSTRHVNVIASNHFQQQQQQHQ 330
                ||||         ||||||                             :.:|..|||||.|
  Fly   728 WGYEPPPPSAGQSHGQHPQQQQQ-----------------------------SPHHQPQQQQQQQ 763

  Fly   331 AQQHQQQHQQHQQ----HQQHVIASVSSSS-SSSAIGSGGSSSSHIFRTPVVSSSSSSNMHHQQQ 390
            .||.|||.||.||    .|||.::|.|:.| :.|:...|||.|......|:..||.:.  .:.::
  Fly   764 QQQSQQQQQQQQQQSLGQQQHCLSSPSAGSLTPSSSSGGGSVSGGGVGGPLTPSSVAP--QNNEE 826

  Fly   391 QQQQQSSLGNS---VMRPPPPP--------------------PPPKVKHASSSSS----GNSSSS 428
            ..|...|||.:   .||..|.|                    ||.:::..:.|:.    |:|:|:
  Fly   827 AAQLLLSLGQTRIQDMRSRPHPFRTPHALNMERLWAGDYSQLPPGQLQALNLSAQQQQWGSSNST 891

  Fly   429 NTNNSSSSSNGEEPSSSIPDLEFDGTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYR 493
            ..........|....:.....:.|...::|.:|.|||:|.|||:.:||||||||:|::|.:..|
  Fly   892 GLGGVGGGMGGRNLEAPHEPTDEDEQPLVCMICEDKATGLHYGIITCEGCKGFFKRTVQNRRVY- 955

  Fly   494 PCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVP----------------KREKARI 542
            .|..:..|.|.:..||||||||.||||..||...|||..|:|                |:.|...
  Fly   956 TCVADGTCEITKAQRNRCQYCRFKKCIEQGMVLQAVREDRMPGGRNSGAVYNLYKVKYKKHKKTN 1020

  Fly   543 LAAMQQSTQNRGQQRALATE--------------------------------------------- 562
            ....||:.|.:.||.|...:
  Fly  1021 QKQQQQAAQQQQQQAAAQQQHQQQQQHQQHQQHQQQQLHSPLHHHHHQGHQSHHAQQQHHPQLSP 1085

  Fly   563 ---LDDQPRLLAAVLRAHLETCEFTKEKVSAMRQRAR------DC------PSYSMPTLLACPL- 611
               |..|.:.|||.:.|..:. :..:::....:|:|:      |.      |:.....|.|.|:
  Fly  1086 HHLLSPQQQQLAAAVAAAAQH-QQQQQQQQQQQQQAKLMGGVVDMKPMFLGPALKPELLQAPPMH 1149

  Fly   612 NPA-----------------------PELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKF 653
            :||                       |..|.:|:..|...|..:......|...|.||.......
  Fly  1150 SPAQQQQQQQQQQQQQQASPHLSLSSPHQQQQQQQGQHQNHHQQQGGGGGGAGGGAQLPPHLVNG 1214

  Fly   654 TLLKAGLFD-ALFVRLICMFDSSINS------------------IICLNGQVMRRDAIQNGAN-- 697
            |:||..|.: :..|.|....||:::|                  |.|        ||:::.|.
  Fly  1215 TILKTALTNPSEIVHLRHRLDSAVSSSKDRQISYEHALGMIQTLIDC--------DAMEDIATLP 1271

  Fly   698 --ARFLVDSTFNFAERMNSMN----------------------------LTDA--EI-------- 722
              :.||.|.: ..:|::.::.                            |||.  ||
  Fly  1272 HFSEFLEDKS-EISEKLCNIGDSIVHKLVSWTKKLPFYLEIPVEIHTKLLTDKWHEILILTTAAY 1335

  Fly   723 ----------------GLFCAIVLITP------------------DRP----------------- 736
                            |...:..|.||                  |.|
  Fly  1336 QALHGKRRGEGGGSRHGSPASTPLSTPTGTPLSTPIPSPAQPLHKDDPEFVSEVNSHLSTLQTCL 1400

  Fly   737 --------GLRNLEL-----IEK------MYSRLK------GCLQYIVAQNR------------- 763
                    .:..|:|     ::|      |:.|:|      .||:..:..|:
  Fly  1401 TTLMGQPIAMEQLKLDVGHMVDKMTQITIMFRRIKLKMEEYVCLKVYILLNKAEVELESIQERYV 1465

  Fly   764 -----------PDQPEF-LAKLLETMPDLRTLSTLHTEKLVVF-------------RTEH----- 798
                       |..|:. |::||..:|:::..::|..|..:.:             ..||
  Fly  1466 QVLRSYLQNSSPQNPQARLSELLSHIPEIQAAASLLLESKMFYVPFVLNSASIRXQMLEHGLLPT 1530

  Fly   799 -----------KELLRQQMWSMEDGNNSDGQQNKSPSGSWADAMDVEAAKSPLGSVSSTESADLD 852
                       ..:..:|....::...|..||::.       ..::...|..:||....|..:.:
  Fly  1531 ANHQSAPPPGPDTIPERQQQQQQERRRSRQQQHQL-------LRNLPKIKIEIGSQRDPEEEESE 1588

  Fly   853 YG-SPSSSQPQGVSLPSPPQQQPSA---------LASSAPLLAATL----------SGGC----P 893
            .. .....|.|.|      |.:|||         |.|.|....|||          |..|    .
  Fly  1589 QELEQEPEQEQDV------QSRPSAASTSILKTSLLSGAAATLATLTAAAEQIARSSASCDTARD 1647

  Fly   894 LRNRANSGSSGDSGAAEMDIVGSHAHLTQNGLTITPIVRHQQQQQQQQQIGILNNAHSRNLNGGH 958
            ....:||.|:.::.......:.|....:.|.|..:..:.|||||||||
  Fly  1648 YSQSSNSSSNSNAATGATGTMASGRTGSSNSLEESKRLEHQQQQQQQQ----------------- 1695

  Fly   959 AMCQQQQQHPQ------LHHHL----------TAGAARYRKLDSPTDSGIESGNEKNECK-AVSS 1006
               ||.|||.|      ||..|          :|.:|......:||.:...|....:..| ||:.
  Fly  1696 ---QQPQQHQQQQYTSILHTALMSQRSMPPATSATSAAAAVTSTPTTAATTSPTPAHVLKTAVTL 1757

  Fly  1007 GGSSSCSSPRSSVDDALDCSDAAANHNQVVQHPQLSVVSVSPVRSPQPSTSSHLKRQIVEDMPVL 1071
            ...|..::.|....:        ....|..|..|..::::    ..|....:.|.|:|:.
  Fly  1758 ASLSEIATARQQQQE--------QQQQQQQQQQQQQLLAM----QQQQQQLTKLPRRIIN----- 1805

  Fly  1072 KRVLQAPPLYDTNSLMDEAYKPHKKFRALRHRE---------FETAEADASSSTSGSNSLSAG-- 1125
                     :.:|...:.|.|      ||....         ..||.|.|:...:....||.|
  Fly  1806 ---------FGSNHTANTATK------ALGAGSEAGAGAGVGMATATATATVGRNRQLGLSQGQV 1855

  Fly  1126 -SPRQSPVPN---------SVATPPPSAASAAAGNPAQSQ---------LHMHLTRSSPKASMAS 1171
             :.|.:.:.|         :..|......:.|..|....|         |...|.:.:|..:.|:
  Fly  1856 VNVRTARLLNGNCCGRLQATAGTGASRGTNTAGSNTVNMQTQTDDELLPLLAMLPQDAPTTTGAA 1920

  Fly  1172 SHSVLAKSLMAEPRMTPEQMKRSDIIQNYLKRENSTAASSTTNGVGNRSPSSSSTPPPSAVQNQQ 1236
            :.:.::.||:|....|                 .::::||:::.:.:.|..|.:|...:.:|.||
  Fly  1921 AGAAVSLSLLATATAT-----------------TTSSSSSSSSSLSSSSTISLATRAAAVMQQQQ 1968

  Fly  1237 RW---------GSSSVITTTCQQRQQSVSPHSNGSSSSSSSSSSSSSSSSSTSSNCSSSSASSCQ 1292
            :|         |.....|||..|.|.:::|.....|........::..:..|:...::::|.:
  Fly  1969 QWTAVSTTPATGVMMTTTTTQSQSQATLAPQQQQLSLPQQKQQFNTRINRKTTITTATTTAPT-- 2031

  Fly  1293 YFQSPHSTSNGTSAPASSSSGSNSATPLLELQVDIADSAQPLNLSKKSPTPPPSKLHALVAAANA 1357
                      .|:|..:::..||                  :|.:..:.....:.::|..|.|:|
  Fly  2032 ----------ATTATTTTTRNSN------------------INFNSNNNYMNNNNINAATARASA 2068

  Fly  1358 VQRYPTLSADVTVTASNGGPPSAAA---SPAPS-SSPPASVGSPNPGLSAAVHKVML 1410
            .     .||....||:..|.|:|..   .|||. ..||.:..:.:..::..|.|.||
  Fly  2069 F-----ASASAMATATPTGTPTATGPRQRPAPQPPPPPRTPTATSASVTVVVFKTML 2120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	44/103 (43%)
Eip75B	NP_001246821.1	NR_LBD_REV_ERB	609..796	CDD:132738	58/385 (15%)
Hr4	NP_001259161.1	NR_DBD_DHR4_like	913..1002	CDD:143542	43/89 (48%)
Hr4	NP_001259161.1	NR_LBD_DHR4_like	1256..1515	CDD:132751	37/267 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910